Cart
sales@molnova.com
VUF11207 fumarate
CAS No. 1785665-61-3
VUF11207 fumarate( —— )
Catalog No. M23800 CAS No. 1785665-61-3
VUF11207 fumarate is an agonist of CXCR7 and a high-potency ligand of CXCR7 (pKi: 8.1).
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 1 mL x 10 mM in DMSO | 93 | In Stock |
|
| 2MG | 48 | In Stock |
|
| 5MG | 76 | In Stock |
|
| 10MG | 132 | In Stock |
|
| 25MG | 273 | In Stock |
|
| 50MG | 462 | In Stock |
|
| 100MG | 666 | In Stock |
|
| 200MG | 926 | In Stock |
|
| 500MG | Get Quote | In Stock |
|
| 1G | Get Quote | In Stock |
|
Biological Information
-
Product NameVUF11207 fumarate
-
NoteResearch use only, not for human use.
-
Brief DescriptionVUF11207 fumarate is an agonist of CXCR7 and a high-potency ligand of CXCR7 (pKi: 8.1).
-
DescriptionVUF11207 fumarate is an agonist of CXCR7 and a high-potency ligand of CXCR7 (pKi: 8.1).
-
In VitroCell Viability Assay Cell Line:Osteoclast precursor cells (RANKL? and TnF?α?induced) Concentration:0.17 nM (100 ng/mL)Incubation Time:5 days Result:Showed inhibitory effect on CXCL12.
-
In VivoAnimal Model:Male c57Bl/6J wild?type/WT mice (8?10?week?old; 20?25 g; LPS-induced)Dosage:100 μg/day Administration:Subcutaneous injection; single daily for 5 days Result:Significantly decreased the number of osteoclasts and suppressed Cathepsin K mRNA, ranKl and TnF?α mRNA expression levels.Reduced the area of LPS-induced bone resorption.
-
Synonyms——
-
PathwayAutophagy
-
TargetCXCR
-
RecptorCXCR7
-
Research Area——
-
Indication——
Chemical Information
-
CAS Number1785665-61-3
-
Formula Weight586.65
-
Molecular FormulaC31H39FN2O8
-
Purity>98% (HPLC)
-
SolubilityDMSO:247 mg/mL (421.03 mM; Need ultrasonic)
-
SMILESC/C(CN(CCC1N(C)CCC1)C(C2=CC(OC)=C(OC)C(OC)=C2)=O)=C\C3=C(F)C=CC=C3.OC(/C=C/C(O)=O)=O
-
Chemical Name——
Shipping & Storage Information
-
Storage(-20℃)
-
ShippingWith Ice Pack
-
Stability≥ 2 years
Reference
1.Wijtmans M, et al. Synthesis, modeling and functional activity of substituted styrene-amides as small-molecule CXCR7 agonists. Eur J Med Chem. 2012 May;51:184-92.
molnova catalog
related products
-
AZD8797
AZD8797 (KAND567) is an orally available, selective and potent human CX3CR1-converting antagonist with inhibitory effects on CX3CR1 and CXCR2.
-
VUF-11222
VUF-11222 is a CXCR3 nonmimetic peptide agonist that induces gliosis.VUF 11222 has been used in the study of retinal inflammation.
-
AMG 487
AMG 487 prevents the chemokines I-IP-10 and I-ITAC from binding to CXCR3.?In the cellular assays, AMG 487 inhibits CXCR3-mediated cell migration with IC50 values of 8nM, 15nM and 36nM for I-IP-10, I-ITAC and MIG, respectively.
