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5-Ph-IAA

CAS No. 168649-23-8

5-Ph-IAA( —— )

Catalog No. M23758 CAS No. 168649-23-8

5-Ph-IAA is a derivative of Indole-3-acetic acid (IAA), which is a plant hormone and acts as an enzyme or prodrug combination for cancer gene therapy.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
Size Price / USD Stock Quantity
1 mL x 10 mM in DMSO 61 In Stock
5MG 55 In Stock
10MG 92 In Stock
25MG 187 In Stock
50MG 306 In Stock
100MG 519 In Stock
200MG Get Quote In Stock
500MG Get Quote In Stock
1G Get Quote In Stock
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Biological Information

  • Product Name
    5-Ph-IAA
  • Note
    Research use only, not for human use.
  • Brief Description
    5-Ph-IAA is a derivative of Indole-3-acetic acid (IAA), which is a plant hormone and acts as an enzyme or prodrug combination for cancer gene therapy.
  • Description
    5-Ph-IAA is a derivative of Indole-3-acetic acid (IAA), which is a plant hormone and acts as an enzyme or prodrug combination for cancer gene therapy.
  • In Vitro
    Western Blot Analysis Cell Line:HCT116 cells Concentration:1 μM Incubation Time:6 hours Result:Depleted DHC1-mAC efficiently in HCT116 cells constitutively expressing OsTIR1(F74G).
  • In Vivo
    Animal Model:Balb/c-nu female mice (7 weeks old; 16–20?g ) bearing mAID-BRD4 and TOP2A-mAC xenograft tumours cells Dosage:0 mg/kg, 1 mg/kg, 3 mg/kg and 10?mg/kg Administration:Intraperitoneally injection; every day; 7 days Result:Displayed significant tumour suppression of mAID-BRD4 xenografts and TOP2A-mAC xenografts.
  • Synonyms
    ——
  • Pathway
    Others
  • Target
    Other Targets
  • Recptor
    Others
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    168649-23-8
  • Formula Weight
    251.28
  • Molecular Formula
    C16H13NO2
  • Purity
    >98% (HPLC)
  • Solubility
    DMSO:125 mg/mL?(497.45 mM;?Need ultrasonic)
  • SMILES
    C1=CC=C(C=C1)C2=CC3=C(C=C2)NC=C3CC(=O)O
  • Chemical Name
    ——

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1.O Greco,et al. Horseradish peroxidase-mediated gene therapy: choice of prodrugs in oxic and anoxic tumor conditions. Mol Cancer Ther. 2001 Dec;1(2):151-60.
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