Cart
sales@molnova.com
LNP023 hydrochloride
CAS No. 1646321-63-2
LNP023 hydrochloride( Iptacopan HCl )
Catalog No. M23738 CAS No. 1646321-63-2
LNP023 hydrochloride is an orally bioavailable, highly potent and highly selective factor B inhibitor with an IC50 of 10 nM.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 1 mL x 10 mM in DMSO | 117 | In Stock |
|
| 2MG | 70 | In Stock |
|
| 5MG | 117 | In Stock |
|
| 10MG | 196 | In Stock |
|
| 25MG | 353 | In Stock |
|
| 50MG | 578 | In Stock |
|
| 100MG | 958 | In Stock |
|
| 200MG | 1293 | In Stock |
|
| 500MG | Get Quote | In Stock |
|
| 1G | Get Quote | In Stock |
|
Biological Information
-
Product NameLNP023 hydrochloride
-
NoteResearch use only, not for human use.
-
Brief DescriptionLNP023 hydrochloride is an orally bioavailable, highly potent and highly selective factor B inhibitor with an IC50 of 10 nM.
-
DescriptionLNP023 hydrochloride is an orally bioavailable, highly potent and highly selective factor B inhibitor with an IC50 of 10 nM. LNP023 shows direct, reversible, and high-affinity binding to human factor B with a KD of 7.9 nM.
-
In Vitro——
-
In VivoAnimal Model:C57BL/6 mice with KRN-induced arthritis Dosage:20, 60, and 180 mg/kg Administration:Orally gavaged; twice a day (b.i.d.) for 14 days Result:Blocked KRN-induced arthritis.
-
SynonymsIptacopan HCl
-
PathwayOthers
-
TargetOther Targets
-
Recptorfactor B
-
Research Area——
-
Indication——
Chemical Information
-
CAS Number1646321-63-2
-
Formula Weight458.98
-
Molecular FormulaC25H31ClN2O4
-
Purity>98% (HPLC)
-
SolubilityDMSO:250 mg/mL (544.69 mM; Need ultrasonic);H2O:50 mg/mL (108.94 mM; ultrasonic and warming)
-
SMILESO=C(O)C1=CC=C([C@H]2N(CC3=C(OC)C=C(C)C4=C3C=CN4)CC[C@H](OCC)C2)C=C1.[H]Cl
-
Chemical Name——
Shipping & Storage Information
-
Storage(-20℃)
-
ShippingWith Ice Pack
-
Stability≥ 2 years
Reference
1.Dimitrios C Mastellos, et al. Expanding Complement Therapeutics for the Treatment of Paroxysmal Nocturnal Hemoglobinuria. Semin Hematol. 2018 Jul;55(3):167-175.
molnova catalog
related products
-
Catalposide
Catalposide is a potent inducer of (HO)-1 isolated from Catalpa ovate G. Don (Bignoniaceae). Catalposide possesses antioxidant, anti-apoptotic, anti-microbial, anti-tumoral, and anti-inflammatory properties.
-
7-Deoxyloganin
7-Deoxyloganin
-
N-Isobutyl decanamid...
N-Isobutyl decanamide (N-Isobutyl N-decanamide) is an amphiphilic derivative belonging to the class of alkanamides with potential anti-inflammatory activity that promotes growth and alters root development in Arabidopsis.
