KI-7( —— )

Catalog No. M23641 CAS No. 1489263-00-4

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Datasheet

HNMR

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Product Name

KI-7
Note

Research use only, not for human use.
Brief Description

KI-7 is an adenosine A2B receptor positive allosteric modulator.
Description

KI-7 is an adenosine A2B receptor positive allosteric modulator.
In Vitro

KI-7 (1 μM; 5-21 days; mesenchymal stem cells) induces a significant increase in mRNA expression of Runx2 and Osterix.KI-7 (1 μM; 15-21 days) induced a significant increase in cell viability in both differentiation stages.KI-7, as A2B adenosine receptor positive allosteric modulator in MSCs, demonstrating it is able to potentiate the effects of either adenosine and synthetic orthosteric A2B adenosine receptor agonists in mediating osteoblast differentiation in vitro. NECA, BAY 60-6583 and KI-7 induce a strong increase in IL-6 production. KI-7 is able to potentiate the effects of orthosteric agonists in both differentiation stages, even if the effect became significant only at 21 days.
In Vivo

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Synonyms

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Pathway

Apoptosis
Target

Adenosine Receptor
Recptor

A2B
Research Area

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Indication

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1.Trincavelli ML, et al. Allosteric modulators of human A2B adenosine receptor. Biochim Biophys Acta. 2014;1840(3):1194-1203.

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