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Tipepidine hydrochloride

CAS No. 1449686-84-3

Tipepidine hydrochloride( —— )

Catalog No. M23615 CAS No. 1449686-84-3

Tipepidine hydrochloride is a reversible inhibitor of dopamine (DA) D2 receptor-mediated GIRK currents (IDA(GIRK)) (IC50: 7.0 μM), with antidepressant-like effect.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
Size Price / USD Stock Quantity
1 mL x 10 mM in DMSO 55 In Stock
2MG 31 In Stock
5MG 49 In Stock
10MG 73 In Stock
25MG 136 In Stock
50MG 219 In Stock
100MG 330 In Stock
200MG Get Quote In Stock
500MG Get Quote In Stock
1G Get Quote In Stock
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Biological Information

  • Product Name
    Tipepidine hydrochloride
  • Note
    Research use only, not for human use.
  • Brief Description
    Tipepidine hydrochloride is a reversible inhibitor of dopamine (DA) D2 receptor-mediated GIRK currents (IDA(GIRK)) (IC50: 7.0 μM), with antidepressant-like effect.
  • Description
    Tipepidine hydrochloride is a reversible inhibitor of dopamine (DA) D2 receptor-mediated GIRK currents (IDA(GIRK)) (IC50: 7.0 μM), with antidepressant-like effect.
  • In Vitro
    ——
  • In Vivo
    Animal Model:Male Wistar rats weighting 150-240 g (5-7 weeks old) Dosage:10, 20 and 40 mg/kg Administration:I.p.; 0.5, 5, 23 hours Result:Decreased the immobility time in the forced swimming test in ACTH-treated rats.
  • Synonyms
    ——
  • Pathway
    GPCR/G Protein
  • Target
    Dopamine Receptor
  • Recptor
    D2
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    1449686-84-3
  • Formula Weight
    311.89
  • Molecular Formula
    C15H18ClNS2
  • Purity
    >98% (HPLC)
  • Solubility
    DMSO:41.67 mg/mL (133.60 mM; Need ultrasonic)
  • SMILES
    CN1C/C(CCC1)=C(C2=CC=CS2)\C3=CC=CS3.[H]Cl
  • Chemical Name
    ——

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1.Hamasaki R, et al. Tipepidine activates VTA dopamine neuron via inhibiting dopamine D? receptor-mediated inward rectifying K? current. Neuroscience. 2013 Nov 12;252:24-34.
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