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Lifirafenib

CAS No. 1446090-79-4

Lifirafenib( Beigene-283 | BGB-283 )

Catalog No. M23610 CAS No. 1446090-79-4

Lifirafenib is a potent inhibitor of RAF family kinases and EGFR in biochemical assays with IC50 of 23, 29 and 495 nM for the recombinant BRAFV600E kinase domain, EGFR and EGFR T790M/L858R mutant respectively.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
Size Price / USD Stock Quantity
1 mL x 10 mM in DMSO 86 In Stock
5MG 60 In Stock
10MG 93 In Stock
25MG 189 In Stock
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Biological Information

  • Product Name
    Lifirafenib
  • Note
    Research use only, not for human use.
  • Brief Description
    Lifirafenib is a potent inhibitor of RAF family kinases and EGFR in biochemical assays with IC50 of 23, 29 and 495 nM for the recombinant BRAFV600E kinase domain, EGFR and EGFR T790M/L858R mutant respectively.
  • Description
    Lifirafenib is a potent inhibitor of RAF family kinases and EGFR in biochemical assays with IC50 of 23, 29 and 495 nM for the recombinant BRAFV600E kinase domain, EGFR and EGFR T790M/L858R mutant respectively.
  • In Vitro
    Lifirafenib (BGB-283) potently inhibits BRafV600E-activated ERK phosphorylation and cell proliferation. It demonstrates selective cytotoxicity and preferentially inhibits proliferation of cancer cells harboring BRafV600E and EGFR mutation/amplification. In BRafV600E colorectal cancer cell lines, Lifirafenib (BGB-283) effectively inhibits the reactivation of EGFR and EGFR-mediated cell proliferation.
  • In Vivo
    Lifirafenib (BGB-283) treatment leads to dose-dependent tumor growth inhibition accompanied by partial and complete tumor regressions in both cell line-derived and primary human colorectal tumor xenografts bearing BRafV600E mutation.
  • Synonyms
    Beigene-283 | BGB-283
  • Pathway
    Angiogenesis
  • Target
    EGFR
  • Recptor
    B-Raf (V600E)|EGFR|EGFR (L858R/T790M)
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    1446090-79-4
  • Formula Weight
    478.42
  • Molecular Formula
    C25H17F3N4O3
  • Purity
    >98% (HPLC)
  • Solubility
    DMSO:100 mg/mL (209.02 mM)
  • SMILES
    O=C1Nc2nccc(Oc(cc3)cc(C45)c3OC4C5c3nc(ccc(C(F)(F)F)c4)c4[nH]3)c2CC1
  • Chemical Name
    ——

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1.Tang Z, et al. Mol Cancer Ther. 2015, 14(10):2187-97.
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