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Isosilybin A
CAS No. 142796-21-2
Isosilybin A( —— )
Catalog No. M23585 CAS No. 142796-21-2
Isosilybin A is a partial PPARγ agonist, it significantly induced ABCA1 protein expression, it inhibited both monophenolase (IC50=1.7-7.6μM) and diphenolase (IC50=12.1-44.9μM) of tyrosinase. Isosilybin A shows anti-angiogenic efficacy, it has anti-prostate cancer (PCA) activity that is mediated via cell cycle arrest and apoptosis induction.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 1 mL x 10 mM in DMSO | 207 | In Stock |
|
| 5MG | 188 | In Stock |
|
| 10MG | 282 | In Stock |
|
| 100MG | Get Quote | In Stock |
|
| 200MG | Get Quote | In Stock |
|
| 500MG | Get Quote | In Stock |
|
| 1G | Get Quote | In Stock |
|
Biological Information
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Product NameIsosilybin A
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NoteResearch use only, not for human use.
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Brief DescriptionIsosilybin A is a partial PPARγ agonist, it significantly induced ABCA1 protein expression, it inhibited both monophenolase (IC50=1.7-7.6μM) and diphenolase (IC50=12.1-44.9μM) of tyrosinase. Isosilybin A shows anti-angiogenic efficacy, it has anti-prostate cancer (PCA) activity that is mediated via cell cycle arrest and apoptosis induction.
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DescriptionIsosilybin A is a partial PPARγ agonist, it significantly induced ABCA1 protein expression, it inhibited both monophenolase (IC50=1.7-7.6μM) and diphenolase (IC50=12.1-44.9μM) of tyrosinase. Isosilybin A shows anti-angiogenic efficacy, it has anti-prostate cancer (PCA) activity that is mediated via cell cycle arrest and apoptosis induction.
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In Vitro——
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In Vivo——
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Synonyms——
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PathwayCell Cycle/DNA Damage
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TargetABC
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RecptorABCA1|PPARγ|Tyrosinase
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Research Area——
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Indication——
Chemical Information
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CAS Number142796-21-2
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Formula Weight482.44
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Molecular FormulaC25H22O10
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Purity>98% (HPLC)
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SolubilityDMSO:90mg/ml(186.55mM; Need ultrasonic)
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SMILESCOc(cc([C@H]1Oc(ccc([C@H]([C@H](C2=O)O)Oc3c2c(O)cc(O)c3)c2)c2O[C@@H]1CO)cc1)c1O
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Chemical Name——
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1.The effect of milk thistle (Silybum marianum) and its main flavonolignans on CYP2C8 enzyme activity in human liver microsomes.Chem Biol Interact. 2017 Jun 1;271:24-29.
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