gamma-Tocotrienol

Research use only, not for human use.

gamma-Tocotrienol is one of the four types of tocotrienol, a type of vitamin E. Itl is also a radioprotector, antioxidant.

gamma-Tocotrienol is one of the four types of tocotrienol, a type of vitamin E. Itl is also a radioprotector, antioxidant. It shows antitumor and antihypertensive effects in vivo.

γ-Tocotrienol (25 μM; 24 h) effectively inhibits the expression levels of mdr1 mRNA and P-gp protein, (25 μM and 50 μM; 24 h) suppresses mdr1 promoter activity and the efflux activity of P-gp as well.γ-Tocotrienol (25 μM and 50 μM; 24 h) reduces the activation of NF-κB signaling pathway and the transcriptional activity of NF-κB.γ-tocotrienol (50 μM; 48 h) effectively inhibits the process of nuclear translocation of p65 which was induced by TNFα. Immunofluorescence Cell Line:MCF-7/Adr cells Concentration:50 μM Incubation Time:48 hours Result:Decreased the red fluorescence of p65 in the nucleus, indicating nuclear translocation inhibiton of p65 induced by TNFα.

γ-Tocotrienol’s liposomal formulation, GT3-Nano (20 mol% γ-Tocotrienol), (10 mg/kg, 6 mol%; i.v.; single dose, observed for 100 d) is highly effective in mitigating the marrow-suppressive effects of sublethal and lethal TBI in mice. GT3-Nano (50 mg/kg; i.v.; ) can facilitate rapid recovery of hematopoietic components in mice treated with the endoradiotherapeutic agent 153Sm-EDTMP. Animal Model:C57/BL6 mice (6-8 weeks old) treated with the whole-body irradiation Dosage:16, 24, 32, and 50 mg/kg Administration:Intravenous injection; observed mice for 100 days Result:Demonstrated dose-dependent radioprotection, achieving 90% survival at 50 mg/kg against lethal 9-Gy of total-body irradiation (TBI).And upregulated progenitor bone marrow cells MPP2 and CMP in GT3-Nano-treated mice.

Plastochromanol | D-gamma-Tocotrienol | gamma-Tocotrienol | gamma Tocotrienol | gammaTocotrienol

Others

Other Targets

Others

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14101-61-2

410.64

C28H42O2

>98% (HPLC)

DMSO:100 mg/mL (243.53 mM; Need ultrasonic)

OC1=C(C)C(C)=C2C(CC[C@](CC/C=C(C)/CC/C=C(C)/CC/C=C(C)/C)(C)O2)=C1

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(-20℃)

With Ice Pack

≥ 2 years