ML277( CID-53347902 )

Catalog No. M23558 CAS No. 1401242-74-7

ML277 was identified as a potent activator of KCNQ1 channels (EC(50)=260 nM).

Purity : >98% (HPLC)

COA

Datasheet

HNMR

HPLC

MSDS

Handing Instructions

Size	Price / USD	Stock	Quantity
1 mL x 10 mM in DMSO	77	In Stock
5MG	67	In Stock
10MG	112	In Stock
25MG	202	In Stock
50MG	299	In Stock
100MG	449	In Stock
200MG	Get Quote	In Stock
500MG	Get Quote	In Stock
1G	Get Quote	In Stock

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Biological Information

Product Name

ML277
Note

Research use only, not for human use.
Brief Description

ML277 was identified as a potent activator of KCNQ1 channels (EC(50)=260 nM).
Description

ML277 was identified as a potent activator of KCNQ1 channels (EC(50)=260 nM).
In Vitro

ML277 (1 μM) increases the amplitude of KCNQ1 whole-cell and single-channel currents.
In Vivo

——
Synonyms

CID-53347902
Pathway

Cell Cycle/DNA Damage
Target

Potassium Channel
Recptor

KCNQ1
Research Area

——
Indication

——

Chemical Information

CAS Number

1401242-74-7
Formula Weight

471.6
Molecular Formula

C23H25N3O4S2
Purity

>98% (HPLC)
Solubility

DMSO:≥60 mg/mL (127.23mM)
SMILES

O=C([C@@H]1N(S(=O)(C2=CC=C(C)C=C2)=O)CCCC1)NC3=NC(C4=CC=C(OC)C=C4)=CS3
Chemical Name

——

Shipping & Storage Information

Storage

(-20℃)
Shipping

With Ice Pack
Stability

≥ 2 years

Reference

1.Mattmann ME, Yu H, Lin Z, et al. Identification of (R)-N-(4-(4-methoxyphenyl)thiazol-2-yl)-1-tosylpiperidine-2-carboxamide, ML277, as a novel, potent and selective K(v)7.1 (KCNQ1) potassium channel activator. Bioorg Med Chem Lett. 2012;22(18):5936-5941. doi:10.1016/j.bmcl.2012.07.060

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