Sarolaner

Research use only, not for human use.

Sarolaner is an orally active and broad-spectrum ectoparasiticide (LC80: 0.3 μg/mL against C. felis and an LC100: 0.003 μg/mL against O. turicata).

Sarolaner is an orally active and broad-spectrum ectoparasiticide (LC80: 0.3 μg/mL against C. felis and an LC100: 0.003 μg/mL against O. turicata).

Cell Viability Assay Cell Line:CHO-K1 cell lines Concentration:450 nM-1 mM Incubation Time:5 min Result:Inhibited GABA-elicited currents at both susceptible (CfRDL-A285) and resistant (CfRDL-S285) flea GABACls with EC50s of 135 and 136 nM, respectively.

Animal Model:Dog infested with R. sanguineus and D. reticulatus Dosage:2.5 mg/kg Administration:Oral gavage; 2.5 mg/kg once Result:Exibited 100% efficacy against R. sanguineus at 48 hours after treatment and also exhibited 98.0% efficacy against D. reticulatus.Animal Model:Dog infested with I. ricinus Dosage:1.25, 2.5 and 5 mg/kg Administration:Oral gavage; 1.25, 2.5 and 5 mg/kg once Result:Exibited 100% efficacy against I. ricinus at all doses until 7 days, and provided over 99.3% reduction against subsequent re-infestations until 57 days at dose of 5.0 and 2.5 mg/kg.

PF-6450567

Others

Other Targets

LC80|LC100

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1398609-39-6

581.36

C23H18Cl2F4N2O5S

>98% (HPLC)

DMSO : 290 mg/mL (498.83 mM; Need ultrasonic)

O=S(CC(N1CC2(OCC3=C2C=CC(C4=NO[C@](C(F)(F)F)(C5=CC(Cl)=C(F)C(Cl)=C5)C4)=C3)C1)=O)(C)=O

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(-20℃)

With Ice Pack

≥ 2 years