Necroptosis-IN-1

CAS No. 1391980-92-9

Necroptosis-IN-1( —— )

Catalog No. M23550 CAS No. 1391980-92-9

Necroptosis-IN-1 is a potent necroptosis inhibitor of RIPK1. It is an analog of Necrostatin-1.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
Size Price / USD Stock Quantity
1 mL x 10 mM in DMSO 144 In Stock
5MG 113 In Stock
10MG 187 In Stock
25MG 318 In Stock
50MG 440 In Stock
100MG 625 In Stock
200MG 823 In Stock
500MG Get Quote In Stock
1G Get Quote In Stock

Biological Information

  • Product Name
    Necroptosis-IN-1
  • Note
    Research use only, not for human use.
  • Brief Description
    Necroptosis-IN-1 is a potent necroptosis inhibitor of RIPK1. It is an analog of Necrostatin-1.
  • Description
    Necroptosis-IN-1 is a potent necroptosis inhibitor of RIPK1. It is an analog of Necrostatin-1.
  • In Vitro
    ——
  • In Vivo
    ——
  • Synonyms
    ——
  • Pathway
    Apoptosis
  • Target
    RIP kinase
  • Recptor
    RIPK1
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    1391980-92-9
  • Formula Weight
    263.68
  • Molecular Formula
    C12H10ClN3O2
  • Purity
    >98% (HPLC)
  • Solubility
    DMSO : 249 mg/mL (944.32 mM; Need ultrasonic)
  • SMILES
    O=C(C(Cc(c1ccc2)c[nH]c1c2Cl)N1)NC1=O
  • Chemical Name
    ——

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1.Jenny L Maki, et al. Fluorescence polarization assay for inhibitors of the kinase domain of receptor interacting protein 1. Anal Biochem. 2012 Aug 15;427(2):164-74.
molnova catalog
related products
  • Necrostatin-5

    Necrostatin-5 (Nec-5) is a selective RIP1 kinase inhibitor and cell necrosis inhibitor that prevents the death of Fadd-deficient Jurkat cells treated with TNF-α, with an EC50 of 240 nM.

  • RIPK2-IN-8

    A potent, selective, orally available RIPK2 inhibitor with IC50 of 3 nM.

  • RIPK1-IN-9

    RIPK1-IN-9 is a potent and selective inhibitor of RIPK1, a dihydronaphthone compound, which inhibits U937 and L929 cells with an IC50 of 2 nM and 1.3 nM, respectively.