Cart
sales@molnova.com
ON1231320
CAS No. 1312471-39-8
ON1231320( GBO-006 )
Catalog No. M23471 CAS No. 1312471-39-8
ON1231320 is a Polo-like kinase 2 (PLK2) inhibitor.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 2MG | 51 | In Stock |
|
| 5MG | 77 | In Stock |
|
| 10MG | 128 | In Stock |
|
| 25MG | 259 | In Stock |
|
| 50MG | 403 | In Stock |
|
| 100MG | 592 | In Stock |
|
| 200MG | Get Quote | In Stock |
|
| 500MG | Get Quote | In Stock |
|
| 1G | Get Quote | In Stock |
|
Biological Information
-
Product NameON1231320
-
NoteResearch use only, not for human use.
-
Brief DescriptionON1231320 is a Polo-like kinase 2 (PLK2) inhibitor.
-
DescriptionON1231320 is a Polo-like kinase 2 (PLK2) inhibitor.
-
In VitroApoptosis Analysis Cell Line:U2OS cells Concentration:0-5 μM Incubation Time:24 hours Result:Increased the activity of Caspases 3/7 in a dose-dependent manner.
-
In VivoAnimal Model:6-8 week old NCR nu/nu female mice with MDAMB-231 triple negative breast cancer cells Dosage:75 mg/kg Administration:IP; alternate days (Q2D) for 20 days Result:Resulted in significant inhibition of tumor growth (86.5%)
-
SynonymsGBO-006
-
PathwayCell Cycle/DNA Damage
-
TargetPLK
-
RecptorPLK2
-
Research Area——
-
Indication——
Chemical Information
-
CAS Number1312471-39-8
-
Formula Weight467.4
-
Molecular FormulaC22H15F2N5O3S
-
Purity>98% (HPLC)
-
SolubilityDMSO:10 mM
-
SMILESCN1C2=NC(=NC=C2C=C(C1=O)S(=O)(=O)C3=C(C=C(C=C3)F)F)NC4=CC5=C(C=C4)NC=C5
-
Chemical Name——
Shipping & Storage Information
-
Storage(-20℃)
-
ShippingWith Ice Pack
-
Stability≥ 2 years
Reference
molnova catalog
related products
-
3MB-PP1
3MB-PP1 is an inhibitor of Polo-like kinase 1 (PLK1) and inhibits Leu93 Mutant Zipper-interacting protein kinase (Leu93-ZIPK) with an IC50 of 2 μM.
-
Plogosertib
Plogosertib (CYC140) is an orally active, selective, potent, and ATP-competitive PLK1 inhibitor with an IC50 value of 3 nM.
-
Cyclapolin 9
Cyclapolin 9 is a selective, potent, and ATP-competitive inhibitor of polo-like kinase 1 (PLK1) with an IC50 of 500 nM, and has not shown activity against other kinases.
