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GNF179
CAS No. 1261114-01-5
GNF179( —— )
Catalog No. M23433 CAS No. 1261114-01-5
GNF179 is an optimized 8,8-dimethyl IP analog.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 1 mL x 10 mM in DMSO | 302 | In Stock |
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| 2MG | 161 | In Stock |
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| 5MG | 275 | In Stock |
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| 10MG | 454 | In Stock |
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| 25MG | 750 | In Stock |
|
| 50MG | 1004 | In Stock |
|
| 100MG | 1376 | In Stock |
|
| 200MG | Get Quote | In Stock |
|
| 500MG | Get Quote | In Stock |
|
| 1G | Get Quote | In Stock |
|
Biological Information
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Product NameGNF179
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NoteResearch use only, not for human use.
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Brief DescriptionGNF179 is an optimized 8,8-dimethyl IP analog.
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DescriptionGNF179 is an optimized 8,8-dimethyl IP analog. It exhibited the potency(4.8 nM against the multidrug resistant strain W2) in vitro metabolic stability and in vivo oral bioavailability.
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In Vitro——
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In VivoAnimal Model:Na?ve Balb/C mice infected with P. berghei Dosage:15 mg/kg Administration:Oral, single dose Result:Protected against an infectious P. berghei sporozoite.Animal Model:Na?ve Balb/C miceDosage:3 or 20 mg/kg Administration:IV or PO (Pharmacokinetic Analysis)Result: Pharmacokinetics of GNF179 in na?ve Balb/C mice.AUC, Area Under the Curve; T1/2, half life; CL, clearance; VSS, steady-state volume of distribution; C0, initial concentration; Cmax maximum concentration; F, fraction of dose absorbed; hrs, hours; nd, not determined.
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Synonyms——
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PathwayMicrobiology/Virology
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TargetParasite
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RecptorParasite
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Research Area——
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Indication——
Chemical Information
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CAS Number1261114-01-5
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Formula Weight427.9
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Molecular FormulaC22H23ClFN5O
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Purity>98% (HPLC)
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SolubilityDMSO:120 mg/mL (280.44 mM)
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SMILESCC(C)(c1nc(-c(cc2)ccc2F)c(Nc(cc2)ccc2Cl)n1CC1)N1C(CN)=O
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Chemical Name——
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1.Meister S, et al. Imaging of Plasmodium liver stages to drive next-generation antimalarial drug discovery. Science. 2011 Dec 9;334(6061):1372-7.
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