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AI-10-47
CAS No. 1256094-31-1
AI-10-47( 1H-Benzimidazole, 2-(2-pyridinyl)-6-(trifluoromethoxy)-AI-10-47 )
Catalog No. M23426 CAS No. 1256094-31-1
AI-10-47 is a small molecule inhibitor of CBFβ-RUNX binding(IC50 : 3.2 μM).
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 1 mL x 10 mM in DMSO | 90 | In Stock |
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| 5MG | 93 | In Stock |
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| 10MG | 164 | In Stock |
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| 25MG | 307 | In Stock |
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| 50MG | 433 | In Stock |
|
| 100MG | 607 | In Stock |
|
| 200MG | 817 | In Stock |
|
| 500MG | Get Quote | In Stock |
|
| 1G | Get Quote | In Stock |
|
Biological Information
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Product NameAI-10-47
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NoteResearch use only, not for human use.
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Brief DescriptionAI-10-47 is a small molecule inhibitor of CBFβ-RUNX binding(IC50 : 3.2 μM).
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DescriptionAI-10-47 is a small molecule inhibitor of CBFβ-RUNX binding(IC50 : 3.2 μM).
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In VitroAI-10-47 (10 μM) weakly inhibits CBFβ-RUNX binding.AI-10-47 significantly inhibits ME-1, TUR, M0-91, THP-1 and U937 cell growth. Western Blot Analysis Cell Line:4 × 106 SEM cells.Concentration:10 μM.Incubation Time:6 h.Result:Weakly reduced CBFβ binding to RUNX1 in cells (may due to its poor solubility).
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In Vivo——
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Synonyms1H-Benzimidazole, 2-(2-pyridinyl)-6-(trifluoromethoxy)-AI-10-47
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PathwayOthers
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TargetOther Targets
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RecptorCBFβ-RUNX binding
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Research Area——
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Indication——
Chemical Information
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CAS Number1256094-31-1
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Formula Weight279.22
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Molecular FormulaC13H8F3N3O
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Purity>98% (HPLC)
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SolubilityDMSO:100 mg/mL (358.14 mM; Need ultrasonic)
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SMILESFC(F)(F)OC1=CC=C2N=C(C3=NC=CC=C3)NC2=C1
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Chemical Name——
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1.Anuradha Illendula, et al. Small Molecule Inhibitor of CBFβ-RUNX Binding for RUNX Transcription Factor Driven Cancers. EBioMedicine. 2016 Jun;8:117-131.
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