AI-10-47( 1H-Benzimidazole, 2-(2-pyridinyl)-6-(trifluoromethoxy)-AI-10-47 )

Catalog No. M23426 CAS No. 1256094-31-1

AI-10-47 is a small molecule inhibitor of CBFβ-RUNX binding(IC50 : 3.2 μM).

Purity : >98% (HPLC)

COA

Datasheet

HNMR

HPLC

MSDS

Handing Instructions

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Biological Information

Product Name

AI-10-47
Note

Research use only, not for human use.
Brief Description

AI-10-47 is a small molecule inhibitor of CBFβ-RUNX binding(IC50 : 3.2 μM).
Description

AI-10-47 is a small molecule inhibitor of CBFβ-RUNX binding(IC50 : 3.2 μM).
In Vitro

AI-10-47 (10 μM) weakly inhibits CBFβ-RUNX binding.AI-10-47 significantly inhibits ME-1, TUR, M0-91, THP-1 and U937 cell growth. Western Blot Analysis Cell Line:4 × 106 SEM cells.Concentration:10 μM.Incubation Time:6 h.Result:Weakly reduced CBFβ binding to RUNX1 in cells (may due to its poor solubility).
In Vivo

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Synonyms

1H-Benzimidazole, 2-(2-pyridinyl)-6-(trifluoromethoxy)-AI-10-47
Pathway

Others
Target

Other Targets
Recptor

CBFβ-RUNX binding
Research Area

——
Indication

——

Chemical Information

CAS Number

1256094-31-1
Formula Weight

279.22
Molecular Formula

C13H8F3N3O
Purity

>98% (HPLC)
Solubility

DMSO:100 mg/mL (358.14 mM; Need ultrasonic)
SMILES

FC(F)(F)OC1=CC=C2N=C(C3=NC=CC=C3)NC2=C1
Chemical Name

——

Shipping & Storage Information

Storage

(-20℃)
Shipping

With Ice Pack
Stability

≥ 2 years

Reference

1.Anuradha Illendula, et al. Small Molecule Inhibitor of CBFβ-RUNX Binding for RUNX Transcription Factor Driven Cancers. EBioMedicine. 2016 Jun;8:117-131.

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