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BPAM344
CAS No. 1204572-55-3
BPAM344( —— )
Catalog No. M23375 CAS No. 1204572-55-3
BPAM344 is a potent positive allosteric modulator (PAM) of the KAR subunits GluK1b, GluK2a, and GluK3a.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 1 mL x 10 mM in DMSO | 48 | In Stock |
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| 2MG | 30 | In Stock |
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| 5MG | 48 | In Stock |
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| 10MG | 79 | In Stock |
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| 25MG | 169 | In Stock |
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| 50MG | 299 | In Stock |
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| 100MG | 432 | In Stock |
|
| 200MG | 604 | In Stock |
|
| 500MG | Get Quote | In Stock |
|
| 1G | Get Quote | In Stock |
|
Biological Information
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Product NameBPAM344
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NoteResearch use only, not for human use.
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Brief DescriptionBPAM344 is a potent positive allosteric modulator (PAM) of the KAR subunits GluK1b, GluK2a, and GluK3a.
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DescriptionBPAM344 is a potent positive allosteric modulator (PAM) of the KAR subunits GluK1b, GluK2a, and GluK3a.
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In VitroBPAM344 potentiates glutamate-evoked currents of GluK2a 21-fold at the highest concentration tested (200 μM), with an EC50 of 79 μM. BPAM344 markedly decreases desensitization kinetics (from 5.5 to 775 ms), whereas it only has a minor effect on deactivation kinetics. BPAM344 (100 μM) also potentiates the peak current amplitude of KAR subunits GluK3a (59-fold), GluK2a (15-fold), GluK1b (5-fold), as well as the AMPA receptor subunit GluA1i (5-fold).
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In Vivo——
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Synonyms——
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PathwayMembrane Transporter/Ion Channel
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TargetiGluR
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RecptorKainate receptor
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Research Area——
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Indication——
Chemical Information
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CAS Number1204572-55-3
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Formula Weight242.27
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Molecular FormulaC10H11FN2O2S
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Purity>98% (HPLC)
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SolubilityIn Vitro:?DMSO : 250 mg/mL (1031.91 mM)
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SMILESFC1=CC=C(C2=C1)N(C3CC3)CNS2(=O)=O
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Chemical Name——
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1.Larsen A P , Fievre S , Frydenvang K , et al. Identification and Structure-Function Study of Positive Allosteric Modulators of Kainate Receptors[J]. Molecular Pharmacology, 2017:mol.116.107599.
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