CDDO-dhTFEA

CAS No. 1191265-33-4

CDDO-dhTFEA( RTA dh404 )

Catalog No. M23361 CAS No. 1191265-33-4

CDDO-dhTFEA is a synthetic oleanane triterpenoid compound which potently activates Nrf2 and inhibits the pro-inflammatory transcription factor NF-κB.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
Size Price / USD Stock Quantity
1 mL x 10 mM in DMSO 187 In Stock
2MG 88 In Stock
5MG 147 In Stock
10MG 255 In Stock
25MG 511 In Stock
50MG 723 In Stock
100MG 1014 In Stock
200MG Get Quote In Stock
500MG 2018 In Stock
1G Get Quote In Stock

Biological Information

  • Product Name
    CDDO-dhTFEA
  • Note
    Research use only, not for human use.
  • Brief Description
    CDDO-dhTFEA is a synthetic oleanane triterpenoid compound which potently activates Nrf2 and inhibits the pro-inflammatory transcription factor NF-κB.
  • Description
    CDDO-dhTFEA is a synthetic oleanane triterpenoid compound which potently activates Nrf2 and inhibits the pro-inflammatory transcription factor NF-κB. It restores hypertension (MAP), increases Nrf2 and expression of its target genes, attenuates activation of NF-κB and transforming growth factor-β pathways, and reduces glomerulosclerosis, interstitial fibrosis and inflammation in the chronic kidney disease (CKD) rats.
  • In Vitro
    ——
  • In Vivo
    ——
  • Synonyms
    RTA dh404
  • Pathway
    Apoptosis
  • Target
    NF-κB
  • Recptor
    NF-κB|Nrf2
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    1191265-33-4
  • Formula Weight
    574.72
  • Molecular Formula
    C33H45F3N2O3
  • Purity
    >98% (HPLC)
  • Solubility
    DMSO:100 mg/mL (174.00 mM; Need ultrasonic)
  • SMILES
    C[C@@]12CC[C@@H]3[C@@]([C@H]1CC(=O)[C@H]4[C@]2(CC[C@@]5([C@H]4CC(CC5)(C)C)C(=O)NCC(F)(F)F)C)(C=C(C(=O)C3(C)C)C#N)C
  • Chemical Name
    ——

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1.Aminzadeh MA, et al. The synthetic triterpenoid RTA dh404 (CDDO-dhTFEA) restores endothelial function impaired by reduced Nrf2 activity in chronic kidney disease. Redox Biol. 2013 Oct 31;1:527-31.
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