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DMT1 blocker 2
CAS No. 1062648-63-8
DMT1 blocker 2( —— )
Catalog No. M23267 CAS No. 1062648-63-8
DMT1 blocker 2, compound 12f, is a direct inhibitor of divalent metal transporter 1 (DMT1) with an IC50 hydrogen peroxide value of 0.83.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 1 mL x 10 mM in DMSO | 215 | In Stock |
|
| 5MG | 188 | In Stock |
|
| 10MG | 353 | In Stock |
|
| 25MG | 598 | In Stock |
|
| 50MG | 833 | In Stock |
|
| 100MG | 1135 | In Stock |
|
| 200MG | Get Quote | In Stock |
|
| 500MG | Get Quote | In Stock |
|
| 1G | Get Quote | In Stock |
|
Biological Information
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Product NameDMT1 blocker 2
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NoteResearch use only, not for human use.
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Brief DescriptionDMT1 blocker 2, compound 12f, is a direct inhibitor of divalent metal transporter 1 (DMT1) with an IC50 hydrogen peroxide value of 0.83.
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DescriptionDMT1 blocker 2, compound 12f, is a direct inhibitor of divalent metal transporter 1 (DMT1) with an IC50 hydrogen peroxide value of 0.83, which is expected to block iron uptake by intestinal epithelial cells in vivo.
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In Vitro——
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In VivoAnimal Model:Weanling (3-4 weeks) rats were placed on a low iron diet for four weeks Dosage:50 mg/kg Administration:Oral gavage followed 1 h later by an iron challenge Result:Attenuated the post-challenge serum iron increase.
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Synonyms——
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PathwayOthers
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TargetOther Targets
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RecptorDMT1
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Research Area——
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Indication——
Chemical Information
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CAS Number1062648-63-8
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Formula Weight263.29
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Molecular FormulaC16H13N3O
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Purity>98% (HPLC)
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SolubilityDMSO:48 mg/mL?(182.3 mM;?Need ultrasonic)
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SMILESOC1=C2C3=CC=CC=C3CCC2=NN1C4=NC=CC=C4
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Chemical Name——
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1.Cadieux JA, et al. Synthesis and biological evaluation of substituted pyrazoles as blockers of divalent metal transporter 1 (DMT1). Bioorg Med Chem Lett. 2012 Jan 1;22(1):90-5.
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