CGS 15943

Research use only, not for human use.

CGS 15943 is an orally bioavailable non-xanthine antagonist of Adenosine Receptor.

CGS 15943 is an orally bioavailable non-xanthine antagonist of Adenosine Receptor. In transfected CHO cells, its Ki for human A1, A2A, A2B, and A3 Adenosine Receptors are 3.5, 4.2, 16, and 50 nM , respectively.

Cell Viability Assay Cell Line:HLF, SK-Hep-1, HepG2 and PLC-PRF-5 cells Concentration:0 μM; 1 μM; 5 μM; 10 μM; 20 μM Incubation Time:24 hours Result:Inhibited growth of four distinct HCC cell lines.Western Blot Analysis Cell Line:HLF and Sk-Hep-1 cells Concentration:0 μM; 1 μM; 5 μM; 10 μM; 20 μM Incubation Time:24 hours Result:Inhibited the PI3K/Akt pathway in HLF and Sk-Hep-1 cells

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Endocrinology/Hormones

AChR

Adenosine A1?receptor|adenosine A2A receptor|adenosine A2B receptor|adenosine A3 receptor|p110γ|p110δ

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104615-18-1

285.69

C13H8ClN5O

>98% (HPLC)

DMSO:12.22 mg/mL (42.77 mM; Need ultrasonic)

C1=COC(=C1)C2=NN3C(=N2)C4=C(C=CC(=C4)Cl)N=C3N

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(-20℃)

With Ice Pack

≥ 2 years