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Sepimostat

CAS No. 103926-64-3

Sepimostat( —— )

Catalog No. M23248 CAS No. 103926-64-3

Sepimostat exhibits neuroprotective activity via NR2B N-methyl-D-aspartate receptor antagonism at the Ifenprodil-binding site of the NR2B subunit.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
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Biological Information

  • Product Name
    Sepimostat
  • Note
    Research use only, not for human use.
  • Brief Description
    Sepimostat exhibits neuroprotective activity via NR2B N-methyl-D-aspartate receptor antagonism at the Ifenprodil-binding site of the NR2B subunit.
  • Description
    Sepimostat exhibits neuroprotective activity via NR2B N-methyl-D-aspartate receptor antagonism at the Ifenprodil-binding site of the NR2B subunit. Sepimostat dimethanesulfonate inhibits the Ifenprodil binding with a Ki value of 27.7 μM.
  • In Vitro
    ——
  • In Vivo
    Sepimostat (1 to 100 nmol/eye, intravitreal injection) exhibits significant neuroprotective effect. Animal Model:Male Sprague Dawley rats weighing 150-300?g.Dosage:Intravitreal injection.Administration:1 to 100 nmol/eye.Result:Exhibited neuroprotective effects significantly.
  • Synonyms
    ——
  • Pathway
    Membrane Transporter/Ion Channel
  • Target
    iGluR
  • Recptor
    NR2B N-methyl-D-aspartate
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    103926-64-3
  • Formula Weight
    373.41
  • Molecular Formula
    C21H19N5O2
  • Purity
    >98% (HPLC)
  • Solubility
    DMSO:6.25 mg/mL?(16.74 mM;?Need ultrasonic)
  • SMILES
    C1CN=C(N1)NC2=CC=C(C=C2)C(=O)OC3=CC4=C(C=C3)C=C(C=C4)C(=N)N
  • Chemical Name
    ——

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1.Masahiro Fuwa, et al. Nafamostat and Sepimostat Identified as Novel Neuroprotective Agents via NR2B N-methyl-D-aspartate Receptor Antagonism Using a Rat Retinal Excitotoxicity Model. Sci Rep. 2019 Dec 31;9(1):20409.
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