TMN355

Research use only, not for human use.

TMN355 is a potent chemical inhibitor of cyclophilin A and reduces foam cell formation and cytokine secretion,and is used for atherosclerosis. Silencing cyclophilin A in THP-1 cells and human monocytes using siRNA or chemical inhibitor, TMN355 resulted in decrease in lipid uptake by 65-75% even after exposure to oxidized LDL.

TMN355 is a potent chemical inhibitor of cyclophilin A and reduces foam cell formation and cytokine secretion,and is used for atherosclerosis. Silencing cyclophilin A in THP-1 cells and human monocytes using siRNA or chemical inhibitor, TMN355 resulted in decrease in lipid uptake by 65-75% even after exposure to oxidized LDL. The expression of scavenger receptors expressed during differentiation process, CD36 and LOX-1 were decreased (p < 0.0001). Levels of extracellular cyclophilin A and other inflammatory cytokines such as TNF-α and MCP-1also significantly reduced. TMN 355 (0.5-10 μM; 3-9 hours) results in 75.9% reduction of cyclophilin A protein expression. And cyclophilin A after 6 h of activation inhibited by TMN 355(1 μM).

TMN 355 (0.5-10 μM; 3-9 hours) results in 75.9% reduction of cyclophilin A protein expression. And 1 μM TMN 355 inhibits cyclophilin A after 6 h of activation.Western Blot Analysis Cell Line:THP cell lines Concentration:0.5, 1, 2.5, 5 and 10 μM Incubation Time:3, 6 and 9 hours Result:Resulted in 75.9% reduction of cyclophilin A protein expression.

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Others

Other Targets

cyclophilin A

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1186372-20-2

380.8

C21H14ClFN2O2

>98% (HPLC)

DMSO:31.25 mg/mL (82.06 mM; Need ultrasonic)

O=C(NC(NC1C2=C(C3=C1C=CC=C3)C=CC=C2)=O)C4=C(F)C=CC=C4Cl

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(-20℃)

With Ice Pack

≥ 2 years