Cart
sales@molnova.com
Home - Products - Angiogenesis - PDE - MR-L2

MR-L2

CAS No. 2374703-19-0

MR-L2( —— )

Catalog No. M22916 CAS No. 2374703-19-0

MR-L2 is a reversible and noncompetitive allosteric activator of long-isoform phosphodiesterase-4 (PDE4).

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
Size Price / USD Stock Quantity
2MG 196 In Stock
5MG 335 In Stock
10MG 500 In Stock
25MG 806 In Stock
50MG 1098 In Stock
100MG 1485 In Stock
500MG 2961 In Stock
1G Get Quote In Stock
Get Quotation Bulk Inquiry Add to Cart

Biological Information

  • Product Name
    MR-L2
  • Note
    Research use only, not for human use.
  • Brief Description
    MR-L2 is a reversible and noncompetitive allosteric activator of long-isoform phosphodiesterase-4 (PDE4).
  • Description
    MR-L2 is a reversible and noncompetitive allosteric activator of long-isoform phosphodiesterase-4 (PDE4).
  • In Vitro
    MR-L2 (0.3-10 μM; 1 h) significantly suppresses cAMP elevation and cysts formation in MDCK cells. Cell Viability Assay Cell Line:Madin-Darby Canine Kidney (MDCK) cell line Concentration:0.3, 1, 3 and 10 μM Incubation Time:1 hour Result:Suppressed cAMP elevation but not enhanced cAMP excretion in MDCK cells. Suppressed cysts formation in MDCK cells with an EC50 value of 1.2 μM. Suppressed the number of cysts formation in 3D culture for both unstimulated and vasopressin-treated culture condition while showed no effect on cell viability.
  • In Vivo
    ——
  • Synonyms
    ——
  • Pathway
    Angiogenesis
  • Target
    PDE
  • Recptor
    PDE4
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    2374703-19-0
  • Formula Weight
    441.71
  • Molecular Formula
    C19H16Cl3FN4O
  • Purity
    >98% (HPLC)
  • Solubility
    In Vitro:?DMSO : 83.33 mg/mL (188.65 mM)
  • SMILES
    ClC1=C(F)C=C(C2=NN(CC(NCC3=CC(Cl)=CC(Cl)=C3)=O)C(CC)=N2)C=C1
  • Chemical Name
    ——

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Omar F, et al. Small-molecule allosteric activators of PDE4 long form cyclic AMP phosphodiesterases. Proc Natl Acad Sci U S A. 2019 Jul 2;116(27):13320-13329.
Calculator

Molecular Weight Calculator

Dilution Calculator

Molarity Calculator

molnova catalog
related products

  • PDE9-IN-(S)-C33

    PDE9-IN-(S)-C33 is a potent and selective inhibitor of PDE9 (IC50 = 11 nM). PDE9-IN-(S)-C33 can be used for central nervous system diseases and diabetes research.

  • CDP-840

    CDP-840 (CDP840;L-765527) is a potent and selective PDE4 inhibitor with IC50 of 4-45 nM for PDE 4 extracted from tissues or recombinant PDE 4 isoforms expressed in yeast.

  • Cudetaxestat

    Cudetaxestat (BLD-0409) is a potent, orally active autotaxin inhibitor.

Sign In Join Free