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Skullcapflavone II
CAS No. 55084-08-7
Skullcapflavone II( —— )
Catalog No. M22798 CAS No. 55084-08-7
Skullcapflavone II is a flavonoid derived from Scutellaria baicalensis, a widely used herbal medicine in anti-inflammatory and anticancer therapy.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 1 mL x 10 mM in DMSO | 230 | In Stock |
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| 5MG | 221 | In Stock |
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| 10MG | 330 | In Stock |
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| 25MG | 550 | In Stock |
|
| 50MG | 767 | In Stock |
|
| 100MG | Get Quote | In Stock |
|
| 200MG | Get Quote | In Stock |
|
| 500MG | Get Quote | In Stock |
|
| 1G | Get Quote | In Stock |
|
Biological Information
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Product NameSkullcapflavone II
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NoteResearch use only, not for human use.
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Brief DescriptionSkullcapflavone II is a flavonoid derived from Scutellaria baicalensis, a widely used herbal medicine in anti-inflammatory and anticancer therapy.
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DescriptionSkullcapflavone II is a flavonoid derived from Scutellaria baicalensis, a widely used herbal medicine in anti-inflammatory and anticancer therapy. Skullcapflavone II may have therapeutic potential for the treatment of allergic asthma.Skullcapflavone II regulates osteoclast differentiation, survival, and function. Skullcapflavone II exerts potent antimicrobial activity against M. aurum and M. bovis BCG.
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In VitroSkullcapflavone II inhibits osteoclastogenesis with decreased activation of MAPKs, Src, and cAMP response element-binding protein (CREB), which have been known to be redox sensitive. Skullcapflavone II decreases reactive oxygen species by scavenging them or activating nuclear factor-erythroid 2-related factor 2 (Nrf2), and its effects were partially reversed by hydrogen peroxide cotreatment or Nrf2 deficiency.
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In VivoSkullcapflavone II, a potential bradykinin antagonist, reduces the major pathophysiological features of allergic asthma, at least in part by acting on TGF-β1/Smad signaling pathways.
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Synonyms——
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PathwayOthers
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TargetOther Targets
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RecptorTGFβ|COX
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Research Area——
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Indication——
Chemical Information
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CAS Number55084-08-7
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Formula Weight374.35
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Molecular FormulaC19H18O8
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Purity>98% (HPLC)
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SolubilityIn Vitro:?DMSO : 50 mg/mL (133.57 mM)
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SMILESCOC1=C2C(C(C=C(C3=C(C=CC=C3O)OC)O2)=O)=C(O)C(OC)=C1OC
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Chemical Name——
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Lee Y H , Seo E K , Lee S T . Skullcapflavone II Inhibits Degradation of Type I Collagen by Suppressing MMP-1 Transcription in Human Skin Fibroblasts[J]. International Journal of Molecular Sciences, 2019, 20(11).
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