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Drotaverine hydrochloride
CAS No. 985-12-6
Drotaverine hydrochloride( —— )
Catalog No. M22762 CAS No. 985-12-6
Drotaverine hydrochloride is a type 4 cyclic nucleotide phosphodiesterase (PDE4) inhibitor,and is an antispasmodic drug, used to enhance cervical dilation during childbirth.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 1 mL x 10 mM in DMSO | 49 | In Stock |
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| 5MG | 45 | In Stock |
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| 10MG | 68 | In Stock |
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| 25MG | 132 | In Stock |
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| 50MG | 245 | In Stock |
|
| 100MG | 365 | In Stock |
|
| 200MG | Get Quote | In Stock |
|
| 500MG | 873 | In Stock |
|
| 1G | Get Quote | In Stock |
|
Biological Information
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Product NameDrotaverine hydrochloride
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NoteResearch use only, not for human use.
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Brief DescriptionDrotaverine hydrochloride is a type 4 cyclic nucleotide phosphodiesterase (PDE4) inhibitor,and is an antispasmodic drug, used to enhance cervical dilation during childbirth.
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DescriptionDrotaverine hydrochloride is a type 4 cyclic nucleotide phosphodiesterase (PDE4) inhibitor，and is an antispasmodic drug, used to enhance cervical dilation during childbirth. Drotaverine hydrochloride is structurally related to papaverine drotaverine not only relaxed the precontracted tracheal preparations but also decreased mediator-induced contraction. These effects of drotaverine were concentration dependent, with a significantly higher potency on the KCl-induced response, than on either the histamine or methacholine induced one. A similar result was noted for nifedipine. The PDE inhibitor, theophylline, also relaxed the precontracted preparations but was ineffective on the mediator-induced contraction in a physiologically relevant concentration range.
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In Vitro——
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In Vivo——
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Synonyms——
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PathwayAngiogenesis
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TargetPDE
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RecptorPDE4
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Research Area——
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Indication——
Chemical Information
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CAS Number985-12-6
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Formula Weight433.97
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Molecular FormulaC24H32ClNO4
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Purity>98% (HPLC)
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SolubilityIn Vitro:?H2O : 100 mg/mL (230.43 mM)
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SMILESCl.CCOc1ccc(cc1OCC)CC2=NCCc3cc(OCC)c(OCC)cc23
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Chemical Name——
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Patai, Zoltán, Guttman, András, Mikus E . Assessment of the Airway Smooth Muscle Relaxant Effect of Drotaverine[J]. Pharmacology, 2018:163.
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