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GR 125743

CAS No. 148547-33-5

GR 125743( —— )

Catalog No. M22737 CAS No. 148547-33-5

GR 125743 is a novel antagonist of 5-HT1B/1D receptor.GR-125743, a new radiolabelled derivative of a compound that exhibits selective antagonistic properties with respect to the serotonin human (h5-HT1D) and human (h5-HT1B) receptors. The compound has been characterized for its ability to label the cloned h5-HT1D and h5-HT1B receptors.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
Size Price / USD Stock Quantity
1 mL x 10 mM in DMSO 85 In Stock
2MG 48 In Stock
5MG 76 In Stock
10MG 116 In Stock
25MG 235 In Stock
50MG 343 In Stock
100MG 511 In Stock
200MG Get Quote In Stock
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Biological Information

  • Product Name
    GR 125743
  • Note
    Research use only, not for human use.
  • Brief Description
    GR 125743 is a novel antagonist of 5-HT1B/1D receptor.GR-125743, a new radiolabelled derivative of a compound that exhibits selective antagonistic properties with respect to the serotonin human (h5-HT1D) and human (h5-HT1B) receptors. The compound has been characterized for its ability to label the cloned h5-HT1D and h5-HT1B receptors.
  • Description
    GR 125743 is a novel antagonist of 5-HT1B/1D receptor.GR-125743, a new radiolabelled derivative of a compound that exhibits selective antagonistic properties with respect to the serotonin human (h5-HT1D) and human (h5-HT1B) receptors. The compound has been characterized for its ability to label the cloned h5-HT1D and h5-HT1B receptors.
  • In Vitro
    GR 125743 has a Kd of 0.61 nM for h5-HT1B.
  • In Vivo
    GR 125743 (0.3 mg/kg; i.p.) produces significant decreases in extracellular 5-HT in the frontal cortex of the conscious guinea pig. Animal Model:Male Dunkin Hartley guinea-pigs (350-450 g)Dosage:0.3 mg/kg Administration:Intraperitoneal injection Result:Produced significant transient increases in extracellular 5-HT.
  • Synonyms
    ——
  • Pathway
    Endocrinology/Hormones
  • Target
    5-HT Receptor
  • Recptor
    5-HT1B/1D
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    148547-33-5
  • Formula Weight
    416.53
  • Molecular Formula
    C25H28N4O2
  • Purity
    >98% (HPLC)
  • Solubility
    In Vitro:?DMSO : 100 mg/mL (240.08 mM)
  • SMILES
    COc1ccc(NC(=O)c2ccc(c(C)c2)-c2ccncc2)cc1N1CCN(C)CC1
  • Chemical Name
    ——

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. T Doménech, J Beleta, J M Palacios,et al.Characterization of human serotonin 1D and 1B receptors using [3H]-GR-125743, a novel radiolabelled serotonin 5HT1D/1B receptor antagonist.Naunyn Schmiedebergs Arch Pharmacol. 1997 Sep;356(3):328-34.
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