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NSI-189 Phosphate
CAS No. 1270138-41-4
NSI-189 Phosphate( NSI189 Phosphate,NSI 189 Phosphate,NSI-189 Phosphate )
Catalog No. M22720 CAS No. 1270138-41-4
NSI-189 Phosphate is a novel neurogenic molecule with pleiotropic properties, including antidepressant, procognitive, synaptoplastic, and neurotrophic activities demonstrated in preclinical studies. Its antidepressant activity is monoamine-independent.NSI-189 actively stimulated remodeling of the stroke brain.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 1 mL x 10 mM in DMSO | 37 | In Stock |
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| 10MG | 34 | In Stock |
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| 25MG | 55 | In Stock |
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| 50MG | 77 | In Stock |
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| 100MG | Get Quote | In Stock |
|
| 200MG | Get Quote | In Stock |
|
| 500MG | Get Quote | In Stock |
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| 1G | Get Quote | In Stock |
|
Biological Information
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Product NameNSI-189 Phosphate
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NoteResearch use only, not for human use.
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Brief DescriptionNSI-189 Phosphate is a novel neurogenic molecule with pleiotropic properties, including antidepressant, procognitive, synaptoplastic, and neurotrophic activities demonstrated in preclinical studies. Its antidepressant activity is monoamine-independent.NSI-189 actively stimulated remodeling of the stroke brain.
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DescriptionNSI-189 Phosphate is a novel neurogenic molecule with pleiotropic properties, including antidepressant, procognitive, synaptoplastic, and neurotrophic activities demonstrated in preclinical studies. Its antidepressant activity is monoamine-independent.NSI-189 actively stimulated remodeling of the stroke brain. Parallel in vitro studies further probed this remodeling process and demonstrated that oxygen glucose deprivation and reperfusion (OGD/R) initiated typical cell death processes, which were reversed by NSI-189 treatment characterized by significant attenuation of OGD/R-mediated hippocampal cell death and increased Ki67 and MAP2 expression, coupled with upregulation of neurogenic factors such as BDNF and SCF. These findings support the use of oral NSI-189 as a therapeutic agent well beyond the initial 6-hr time window to accelerate and enhance the overall functional improvement in the initial 6 months post stroke.
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In Vitro——
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In Vivo——
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SynonymsNSI189 Phosphate,NSI 189 Phosphate,NSI-189 Phosphate
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PathwayOthers
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TargetOther Targets
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RecptorOthers
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Research Area——
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Indication——
Chemical Information
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CAS Number1270138-41-4
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Formula Weight464.5
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Molecular FormulaC22H33N4O5P
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Purity>98% (HPLC)
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SolubilityDMSO:Soluble
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SMILESOP(O)(O)=O.CC(C)CCNc1ncccc1C(=O)N1CCN(Cc2ccccc2)CC1
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Chemical Name——
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Tajiri N , Quach D M , Kaneko Y , et al. NSI‐189, a small molecule with neurogenic properties, exerts behavioral, and neurostructural benefits in stroke rats[J]. Journal of Cellular Physiology, 2017.
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