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GPNA hydrochloride
CAS No. 67953-08-6
GPNA hydrochloride( —— )
Catalog No. M22681 CAS No. 67953-08-6
GPNA hydrochloride is specific glutamine (Gln) transporter ASCT2(SLC1A5) inhibitor. GPNA reversibly induces apoptosis in A549 cells. GPNA hydrochloride is a well-known substrate of the enzyme γ-glutamyltransferase (GGT).
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 10MG | 29 | In Stock |
|
| 25MG | 58 | In Stock |
|
| 50MG | 99 | In Stock |
|
| 100MG | 137 | In Stock |
|
| 200MG | Get Quote | In Stock |
|
| 500MG | 342 | In Stock |
|
| 1G | Get Quote | In Stock |
|
Biological Information
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Product NameGPNA hydrochloride
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NoteResearch use only, not for human use.
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Brief DescriptionGPNA hydrochloride is specific glutamine (Gln) transporter ASCT2(SLC1A5) inhibitor. GPNA reversibly induces apoptosis in A549 cells. GPNA hydrochloride is a well-known substrate of the enzyme γ-glutamyltransferase (GGT).
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DescriptionGPNA hydrochloride is specific glutamine (Gln) transporter ASCT2(SLC1A5) inhibitor. GPNA reversibly induces apoptosis in A549 cells. GPNA hydrochloride is a well-known substrate of the enzyme γ-glutamyltransferase (GGT). GPNA hydrochloride also inhibits Na+-dependent carriers, such as SNAT family (SNAT1/2/4/5), and the Na+-independent leucine transporters LAT1/2.GPNA (10-1000 μM; 48 hours) induces a dose-dependent to reduce of cell viability in A549 cells.
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In VitroGPNA (10-1000 μM; 48hours) induces a dose-dependent decrease of cell viability in A549 cells. Cell Viability AssayCell Line:A549 cells Concentration:10, 100, 250, 500 , and 1000 μM Incubation Time:48?hours Result:Induced a dose-dependent decrease of cell viability, with an IC50 roughly corresponding to ~250?μM.
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In Vivo——
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Synonyms——
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PathwayOthers
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TargetOther Targets
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RecptorASCT2
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Research Area——
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Indication——
Chemical Information
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CAS Number67953-08-6
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Formula Weight303.7
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Molecular FormulaC11H14ClN3O5
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Purity>98% (HPLC)
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SolubilityDMSO:124 mg/mL(408.3 mM)
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SMILESCl.N[C@@H](CCC(=O)Nc1ccc(cc1)[N+]([O-])=O)C(O)=O
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Chemical Name——
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Corti A, et al. γ-Glutamyltransferase enzyme activity of cancer cells modulates L-γ-glutamyl-p-nitroanilide (GPNA) cytotoxicity. Sci Rep. 2019 Jan 29;9(1):891.
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