Cart
sales@molnova.com
LIT-001
CAS No. 2245072-21-1
LIT-001( —— )
Catalog No. M22581 CAS No. 2245072-21-1
LIT-001 improves social interaction in a mouse model of autism.It is the first nonpeptide oxytocin receptor agonist with EC50 of 55 nM and Ki of 226 nM.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 5MG | 140 | In Stock |
|
| 10MG | 258 | In Stock |
|
| 25MG | 410 | In Stock |
|
| 50MG | 605 | In Stock |
|
| 100MG | 860 | In Stock |
|
| 500MG | 1728 | In Stock |
|
| 1G | Get Quote | In Stock |
|
Biological Information
-
Product NameLIT-001
-
NoteResearch use only, not for human use.
-
Brief DescriptionLIT-001 improves social interaction in a mouse model of autism.It is the first nonpeptide oxytocin receptor agonist with EC50 of 55 nM and Ki of 226 nM.
-
DescriptionLIT-001 improves social interaction in a mouse model of autism.It is the first nonpeptide oxytocin receptor agonist with EC50 of 55 nM and Ki of 226 nM.In the in vitro signal transduction experiment, LITL-001 is an unbiased OT-R agonist, acting on the two main signal transduction pathways of this receptor, with slight antagonistic effect on V1a and agonist effect on V1b receptor, only observed at high concentration.LIT-001 (10-20 mg/kg; i.p.) alleviates core symptoms in the context of autism spectrum disorders (ASD).
-
In VitroIn vitro signaling experiments, LIT-001 is a nonbiased OT-R agonist on the two main signaling pathways of this receptor, with minor antagonist effect on V1a and agonist effect on V1b receptors, observed at high concentrations only.
-
In VivoLIT-001 (10-20 mg/kg; i.p.) alleviates core symptoms in the context of autism spectrum disorders (ASD ). Animal Model:Oprm1–/– mice (bred in house on a 50% 129SVPas–50% C57BL/6J hybrid background) Dosage:10, 20 mg/kg Administration:i.p.Result:Alleviated core symptoms in the context of ASD.
-
Synonyms——
-
PathwayOthers
-
TargetOther Targets
-
Recptoroxytocin receptor
-
Research Area——
-
Indication——
Chemical Information
-
CAS Number2245072-21-1
-
Formula Weight645.7
-
Molecular FormulaC30H34F3N7O4S
-
Purity>98% (HPLC)
-
SolubilityDMSO:247 mg/mL (382.53mM; Need ultrasonic)
-
SMILESOC(=O)C(F)(F)F.CN(C)C(=S)[C@@H]1CCCN1C(=O)NCc1ccc(cc1C)C(=O)N1Cc2cnn(C)c2Nc2ccccc12
-
Chemical Name——
Shipping & Storage Information
-
Storage(-20℃)
-
ShippingWith Ice Pack
-
Stability≥ 2 years
Reference
1.Frantz MC, et al. LIT-001, the First Nonpeptide Oxytocin Receptor Agonist that Improves Social Interaction in a Mouse Model of Autism. J Med Chem. 2018 Oct 11;61(19):8670-8692.
molnova catalog
related products
-
SV40 Nuclear Transpo...
Cys-Gly-Tyr-Gly-Pro-Lys-Lys-Lys-Arg-Lys-Val-Gly-Gly is a13-mer synthetic peptide containing seven amino acids homologous to SV40 T antigen. Cys-Gly-Tyr-Gly-Pro-Lys-Lys-Lys-Arg-Lys-Val-Gly-Gly is capable of inducing nuclear transport.
-
H-HoArg-OH
H-HoArg-OH a homologue arginine is a strong inhibitor of human bone and liver alkaline phosphatase.
-
Neuropeptide Y (29-6...
Neuropeptide Y (29-64), amide, human (TFA) is involved in Alzheimer's disease (AD) and protects rat cortical neurons against β-Amyloid toxicity.It is showed that Neuropeptide Y (29-64), amide, human (TFA) is able to protect cortical neurons from Aβ25-35 toxicity.
