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Indolelactic acid
CAS No. 1821-52-9
Indolelactic acid( —— )
Catalog No. M22552 CAS No. 1821-52-9
Indolelactic acid is a metabolite of tryptophan in Azotobacter vinelandii cultures.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
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Biological Information
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Product NameIndolelactic acid
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NoteResearch use only, not for human use.
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Brief DescriptionIndolelactic acid is a metabolite of tryptophan in Azotobacter vinelandii cultures.
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DescriptionIndolelactic acid is a metabolite of tryptophan in Azotobacter vinelandii cultures.
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In VitroIndolelactic acid (1 mM, 5 days) upregulates CXCR3, granzyme B, and immunoregulatory galectin-1 in Th2 cells.Indolelactic acid (0.1-10mM, 1 h) significantly inhibits LPS-induced inflammation in RAW blue macrophages and Caco-2 cells.Indolelactic acid (0.1-10mM, 1 h) inhibits TNF-α induced inflammation in HT-29 cells.Indolelactic acid (10mM, 1 h) activates the AhR and downstream Nrf2 pathway in Caco-2 cells.Indolelactic acid (5 μM, 24 h) enhances the IFIT2 and RSAD2 mRNA expression in H4 cells stimulated by IL-1β. RT-PCR Cell Line:HT-29 cells Concentration:0.1, 1, 10?mMIncubation Time:1 h Result:Decreased IL-8 level induced by TNF-α, and increased β-defensin 2 and SERT level.
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In VivoIndolelactic acid (gavage feeding, 10 μM, 5 μL, 5 days, C57BL/6 mice) benefits the immature intestine preferentially. Animal Model:C57BL/6 mice Dosage:10 μM, 5 μL Administration:Gavage feeding, 5 days Result:Upregulated the innate immune response genes in immature mouse intestine (C57-pup-ileum), with no effects on pup-colon or adult intestine.
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Synonyms——
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PathwayProteasome/Ubiquitin
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TargetEndogenous Metabolite
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RecptorEndogenous Metabolite
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Research Area——
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Indication——
Chemical Information
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CAS Number1821-52-9
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Formula Weight205.21
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Molecular FormulaC11H11NO3
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Purity>98% (HPLC)
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SolubilityDMSO:82 mg/mL (399.59mM; Need ultrasonic)
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SMILESO=C(O)C(O)Cc2cnc1ccccc12
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Chemical Name——
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1.Francisco García-Tabares, et al. Production of 3-indoleacetic acid and 3-indolelactic acid in Azotobacter vinelandii cultures supplemented with tryptophan. Appl Microbiol Biotechnol.1987 Mar, 25 (6):502–506.
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