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ML390
CAS No. 2029049-79-2
ML390( —— )
Catalog No. M22425 CAS No. 2029049-79-2
ML390 exerts its potent differentiation effect on multiple leukemia models.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 1 mL x 10 mM in DMSO | 29 | In Stock |
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| 10MG | 39 | In Stock |
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| 25MG | 69 | In Stock |
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| 50MG | 105 | In Stock |
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| 100MG | 188 | In Stock |
|
| 200MG | Get Quote | In Stock |
|
| 500MG | Get Quote | In Stock |
|
| 1G | Get Quote | In Stock |
|
Biological Information
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Product NameML390
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NoteResearch use only, not for human use.
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Brief DescriptionML390 exerts its potent differentiation effect on multiple leukemia models.
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DescriptionML390 exerts its potent differentiation effect on multiple leukemia models.
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In VitroML390 is active with an ED50 of ~2 μM in murine and human AML cell lines. In vitro, treatment of Lys-GFP-ER-HoxA9 cells with ML390 for 48 hr inhibits DHODH activity, leading to the dramatic (>500-fold) accumulation of the upstream metabolite DHO and the depletion of uridine and other downstream metabolites.
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In Vivo——
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Synonyms——
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PathwayOthers
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TargetOther Targets
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RecptorOthers
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Research Area——
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Indication——
Chemical Information
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CAS Number2029049-79-2
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Formula Weight406.4
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Molecular FormulaC21H21F3N2O3
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Purity>98% (HPLC)
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SolubilityDMSO:27 mg/mL (66.44 mM)
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SMILESFC(F)(F)Oc1ccc(cc1)C(=O)NCCC(=O)N[C@@H]1CCCc2ccccc12
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Chemical Name——
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Sykes DB et al. Discovering Small Molecules that Overcome Differentiation Arrest in Acute Myeloid Leukemia. National Center for Biotechnology Information (US); 2010-2013 Dec 15.
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