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ML390

CAS No. 2029049-79-2

ML390( —— )

Catalog No. M22425 CAS No. 2029049-79-2

ML390 exerts its potent differentiation effect on multiple leukemia models.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
Size Price / USD Stock Quantity
1 mL x 10 mM in DMSO 29 In Stock
10MG 39 In Stock
25MG 69 In Stock
50MG 105 In Stock
100MG 188 In Stock
200MG Get Quote In Stock
500MG Get Quote In Stock
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Biological Information

  • Product Name
    ML390
  • Note
    Research use only, not for human use.
  • Brief Description
    ML390 exerts its potent differentiation effect on multiple leukemia models.
  • Description
    ML390 exerts its potent differentiation effect on multiple leukemia models.
  • In Vitro
    ML390 is active with an ED50 of ~2 μM in murine and human AML cell lines. In vitro, treatment of Lys-GFP-ER-HoxA9 cells with ML390 for 48 hr inhibits DHODH activity, leading to the dramatic (>500-fold) accumulation of the upstream metabolite DHO and the depletion of uridine and other downstream metabolites.
  • In Vivo
    ——
  • Synonyms
    ——
  • Pathway
    Others
  • Target
    Other Targets
  • Recptor
    Others
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    2029049-79-2
  • Formula Weight
    406.4
  • Molecular Formula
    C21H21F3N2O3
  • Purity
    >98% (HPLC)
  • Solubility
    DMSO:27 mg/mL (66.44 mM)
  • SMILES
    FC(F)(F)Oc1ccc(cc1)C(=O)NCCC(=O)N[C@@H]1CCCc2ccccc12
  • Chemical Name
    ——

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Sykes DB et al. Discovering Small Molecules that Overcome Differentiation Arrest in Acute Myeloid Leukemia. National Center for Biotechnology Information (US); 2010-2013 Dec 15.
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