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SSD114 hydrochloride
CAS No. 2319790-02-6
SSD114 hydrochloride( —— )
Catalog No. M22387 CAS No. 2319790-02-6
SSD114 hydrochloride is a GABAB receptor positive allosteric modulator.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 1 mL x 10 mM in DMSO | 39 | In Stock |
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| 2MG | 29 | In Stock |
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| 5MG | 46 | In Stock |
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| 10MG | 69 | In Stock |
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| 25MG | 113 | In Stock |
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| 50MG | 177 | In Stock |
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| 100MG | 300 | In Stock |
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| 200MG | 433 | In Stock |
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| 500MG | Get Quote | In Stock |
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| 1G | Get Quote | In Stock |
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Biological Information
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Product NameSSD114 hydrochloride
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NoteResearch use only, not for human use.
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Brief DescriptionSSD114 hydrochloride is a GABAB receptor positive allosteric modulator.
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DescriptionSSD114 hydrochloride is a GABAB receptor positive allosteric modulator.
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In VitroIn the presence of 10 μM GABA, SSD114 hydrochloride at 25 μM significantly increases (to approximately 170% above basal levels) the [35S]GTPγS stimulation induced by GABA alone. SSD114 hydrochloride, added at 15 and 30 μM, induces a leftward shift of the GABA concentration-response curve with a slight concomitant increase of maximal GABA stimulation at the highest concentration. In the presence of both 15 and 30 μM SSD114 hydrochloride, the EC50 for GABA decreases by 2 and 2.5 fold, respectively, while the maximal stimulation (Emax) is potentiated only at the concentration of 30 μM, reaching 161±5.09% over the basal value .
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In VivoThe onset of loss of righting reflex (LORR) is reduced by pretreatment with SSD114 hydrochloride [F(5,30)=4.55, P<0.005]. Post hoc analysis indicates that the onset of LORR is significantly lower in mouse groups pretreated with doses of SSD114 hydrochloride equal to or higher than 10 mg/kg than in vehicle-treated mice. The duration of LORR is increased by pretreatment with SSD114 hydrochloride [F(5,30)=4.81, P<0.005]. Post hoc analysis indicates that the duration of LORR is significantly longer in mouse groups pretreated with 10 and 100 mg/kg SSD114 hydrochloride than in vehicle-treated mice.
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Synonyms——
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PathwayOthers
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TargetOther Targets
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RecptorGABA
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Research Area——
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Indication——
Chemical Information
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CAS Number2319790-02-6
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Formula Weight387.83
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Molecular FormulaC18H21ClF3N3O
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Purity>98% (HPLC)
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SolubilityDMSO:130 mg/mL (335.20 mM; Need ultrasonic)
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SMILESCl.COc1cc(nc(NC2CCCCC2)n1)-c1ccc(cc1)C(F)(F)F
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Chemical Name——
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1.Porcu A, et al. In vitro and in vivo pharmacological characterization of SSD114, a novel GABAB positive allosteric modulator. Eur J Pharmacol. 2016 Nov 15;791:115-123.
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