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(S,R,S)-AHPC-PEG3-N3

CAS No. 1797406-80-4

(S,R,S)-AHPC-PEG3-N3( VH032-PEG3-N3 )

Catalog No. M22360 CAS No. 1797406-80-4

(S,R,S)-AHPC-PEG3-N3 is a synthesized E3 ligase ligand-linker conjugate that incorporates the (S,R,S)-AHPC based VHL ligand and 3-unit PEG linker used in PROTAC technology. (S,R,S)-AHPC-PEG3-N3 is extracted from patent WO/2016/146985A1.

Purity : >98% (HPLC)

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Biological Information

  • Product Name
    (S,R,S)-AHPC-PEG3-N3
  • Note
    Research use only, not for human use.
  • Brief Description
    (S,R,S)-AHPC-PEG3-N3 is a synthesized E3 ligase ligand-linker conjugate that incorporates the (S,R,S)-AHPC based VHL ligand and 3-unit PEG linker used in PROTAC technology. (S,R,S)-AHPC-PEG3-N3 is extracted from patent WO/2016/146985A1.
  • Description
    (S,R,S)-AHPC-PEG3-N3 is a synthesized E3 ligase ligand-linker conjugate that incorporates the (S,R,S)-AHPC based VHL ligand and 3-unit PEG linker used in PROTAC technology. (S,R,S)-AHPC-PEG3-N3 is extracted from patent WO/2016/146985A1. PROTAC has been developed having structure A-L-B that can tether a bromodomain inhibitor via a moiety which binds to a protein within the bromo- and Extra-terminal (BET) family of proteins to a small molecule E3 ubiquintin ligase protein binding ligand compond via a suitable linker.
  • In Vitro
    (S,R,S)-AHPC-PEG3-N3 is extracted from patent WO/2016/146985A1, figure 11. PROTAC has been developed having structure A-L-B that can tether a bromodomain inhibitor via a moiety which binds to a protein within the bromo- and Extra-terminal (BET) family of proteins to a small molecule E3 ubiquintin ligase protein binding ligand compond via a suitable linker.
  • In Vivo
    ——
  • Synonyms
    VH032-PEG3-N3
  • Pathway
    PROTACs
  • Target
    PROTAC
  • Recptor
    VHL
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    1797406-80-4
  • Formula Weight
    645.77
  • Molecular Formula
    C30H43N7O7S
  • Purity
    >98% (HPLC)
  • Solubility
    DMSO:50 mg/mL (77.43 mM; Need ultrasonic)
  • SMILES
    O=C(N[C@@H](C(C)(C)C)C(N(C[C@H](O)C1)[C@@H]1C(NCC2=CC=C(C(SC=N3)=C3C)C=C2)=O)=O)COCCOCCOCCN=[N+]=[N-]
  • Chemical Name
    ——

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. CIULLI, Alessio, et al. DERIVATIVES OF 1-[(CYCLOPENTYL OR 2-PYRROLIDINYL)CARBONYLAMINOMETHYL]-4-(1,3-THIAZOL-5-YL) BENZENE WHICH ARE USEFUL FOR THE TREATMENT OF PROLIFERATIVE, AUTOIMMUNE OR INFLAMMATORY DISEASES. WO2016146985A1.
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