Benzotript

Research use only, not for human use.

Benzotript is an gastrin-receptor antagonist, with anti-gastrinic.proglumide and benzotript, a new tryptophan derivative, to inhibit acid output from isolated gastric fundic parietal cells from rabbit.

Benzotript is an gastrin-receptor antagonist, with anti-gastrinic.proglumide and benzotript, a new tryptophan derivative, to inhibit acid output from isolated gastric fundic parietal cells from rabbit. As measured with the [14C]aminopyrine (AP) accumulation method as an index of acid secretion, the two drugs inhibited basal AP with IC-50 values of 1 X 10(-2) M for proglumide and 1 X 10(-3) M for benzotript. In the case of secretagogue stimulation (1) benzotript slightly affected histamine-induced AP (15% inhibition at 5 X 10(-3) M), proglumide did not; (2) both proglumide and benzotript inhibited in a non-competitive manner acetylcholine-induced AP; (3) these isolated cells were sensitive to gastrin and the dose-response curve for the stimulant was biphasic (maximum for 1 X 10(-9) M), suggesting a desensitization mechanism. Proglumide and benzotript competitively inhibited both [125I]gastrin binding to its receptor sites and gastrin-induced AP, suggesting they are members of a class of gastrin-receptor antagonists.

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Others

Other Targets

gastrin-receptor

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39544-74-6

342.78

C18H15ClN2O3

>98% (HPLC)

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O=C(O)[C@H](CC1=CNC2=C1C=CC=C2)NC(C3=CC=C(Cl)C=C3)=O

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(-20℃)

With Ice Pack

≥ 2 years