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NSC 65809
CAS No. 94023-67-3
NSC 65809( 3-[(2,3-dichlorophenyl)methylene]carbazamidine )
Catalog No. M22219 CAS No. 94023-67-3
Raphin1 is a selective inhibitor of R15B.In cells, Raphin1 caused a rapid and transient accumulation of its phosphorylated substrate, resulting in a transient attenuation of protein synthesis.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 1 mL x 10 mM in DMSO | 152 | In Stock |
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| 5MG | 170 | In Stock |
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| 10MG | 258 | In Stock |
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| 25MG | 426 | In Stock |
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| 50MG | 586 | In Stock |
|
| 100MG | 792 | In Stock |
|
| 200MG | 1051 | In Stock |
|
| 500MG | Get Quote | In Stock |
|
| 1G | Get Quote | In Stock |
|
Biological Information
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Product NameNSC 65809
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NoteResearch use only, not for human use.
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Brief DescriptionRaphin1 is a selective inhibitor of R15B.In cells, Raphin1 caused a rapid and transient accumulation of its phosphorylated substrate, resulting in a transient attenuation of protein synthesis.
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DescriptionRaphin1 is a selective inhibitor of R15B.In cells, Raphin1 caused a rapid and transient accumulation of its phosphorylated substrate, resulting in a transient attenuation of protein synthesis. In vitro, Raphin1 inhibits the recombinant R15B-PP1c holoenzyme, but not the closely related R15A-PP1c, by interfering with substrate recruitmentRaphin1 was orally bioavailable, crossed the blood-brain barrier, and demonstrated efficacy in a mouse model of Huntington's disease.
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In Vitro——
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In Vivo——
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Synonyms3-[(2,3-dichlorophenyl)methylene]carbazamidine
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PathwayOthers
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TargetOther Targets
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RecptorR15B
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Research Area——
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Indication——
Chemical Information
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CAS Number94023-67-3
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Formula Weight231.08
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Molecular FormulaC8H8Cl2N4
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Purity>98% (HPLC)
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Solubility——
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SMILESNC(=N)N/N=C/c1cccc([Cl])c1[Cl]
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Chemical Name——
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1.Agnieszka Krzyzosiak, Anna Sigurdardottir, Laura Luh.et al.Target-Based Discovery of an Inhibitor of the Regulatory Phosphatase PPP1R15B.Cell. 2018 Aug 23;174(5):1216-1228.e19.
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