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L524-0366
CAS No. 951612-19-4
L524-0366( [1-(3-chlorophenyl)triazol-4-yl]-thiomorpholino-methanone )
Catalog No. M22217 CAS No. 951612-19-4
L524-0366 is a TWEAK-Fn14 signaling cascade inhibitor.L524-0366 mitigated maladaptive remodeling with TAC. TWEAK induced secretion of the pro-inflammatory chemokine, monocyte chemoattractant protein 1 from WT but not Fn14-/- fibroblasts in vitro, in part through activation of non-canonical NF-κB signaling.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 1 mL x 10 mM in DMSO | 242 | In Stock |
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| 5MG | 235 | In Stock |
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| 10MG | 359 | In Stock |
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| 25MG | 620 | In Stock |
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| 50MG | 830 | In Stock |
|
| 100MG | 1097 | In Stock |
|
| 200MG | 1507 | In Stock |
|
| 500MG | Get Quote | In Stock |
|
| 1G | Get Quote | In Stock |
|
Biological Information
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Product NameL524-0366
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NoteResearch use only, not for human use.
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Brief DescriptionL524-0366 is a TWEAK-Fn14 signaling cascade inhibitor.L524-0366 mitigated maladaptive remodeling with TAC. TWEAK induced secretion of the pro-inflammatory chemokine, monocyte chemoattractant protein 1 from WT but not Fn14-/- fibroblasts in vitro, in part through activation of non-canonical NF-κB signaling.
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DescriptionL524-0366 is a TWEAK-Fn14 signaling cascade inhibitor.L524-0366 mitigated maladaptive remodeling with TAC. TWEAK induced secretion of the pro-inflammatory chemokine, monocyte chemoattractant protein 1 from WT but not Fn14-/- fibroblasts in vitro, in part through activation of non-canonical NF-κB signaling. Finally, Fn14 expression was increased in mouse following TAC and in human failing hearts.
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In Vitro——
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In Vivo——
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Synonyms[1-(3-chlorophenyl)triazol-4-yl]-thiomorpholino-methanone
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PathwayOthers
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TargetOther Targets
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RecptorFn14
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Research Area——
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Indication——
Chemical Information
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CAS Number951612-19-4
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Formula Weight308.79
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Molecular FormulaC13H13ClN4OS
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Purity>98% (HPLC)
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Solubility——
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SMILESO=C(C1=CN(C2=CC=CC(Cl)=C2)N=N1)N3CCSCC3
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Chemical Name——
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1.Unudurthi S D , Nassal D M , Patel N J , et al. Fibroblast growth factor-inducible 14 mediates macrophage infiltration in heart to promote pressure overload-induced cardiac dysfunction[J]. Life ences, 2020, 247:117440.
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