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HJC0197
CAS No. 1383539-73-8
HJC0197( —— )
Catalog No. M22183 CAS No. 1383539-73-8
HJC0197 selectively blocks cAMP-induced Epac activation. HJC0197 is an effective exchange protein. Which straightly activated by cAMP (Epac) antagonist (IC50=5.9 μM for Epac2).
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 1 mL x 10 mM in DMSO | 55 | In Stock |
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| 2MG | 30 | In Stock |
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| 5MG | 47 | In Stock |
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| 10MG | 74 | In Stock |
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| 25MG | 130 | In Stock |
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| 50MG | 184 | In Stock |
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| 100MG | 276 | In Stock |
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| 200MG | 418 | In Stock |
|
| 500MG | Get Quote | In Stock |
|
| 1G | Get Quote | In Stock |
|
Biological Information
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Product NameHJC0197
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NoteResearch use only, not for human use.
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Brief DescriptionHJC0197 selectively blocks cAMP-induced Epac activation. HJC0197 is an effective exchange protein. Which straightly activated by cAMP (Epac) antagonist (IC50=5.9 μM for Epac2).
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DescriptionHJC0197 selectively blocks cAMP-induced Epac activation. HJC0197 is an effective exchange protein. Which straightly activated by cAMP (Epac) antagonist (IC50=5.9 μM for Epac2). In the presence of an equal concentration of cAMP, HJC0197 (25 μM) also inhibits Epac1-mediated Rap1-GDP exchange activity at 25 μM.
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In VitroHJC0197 (25 μM) also inhibits Epac1-mediated Rap1-GDP exchange activity at 25 μM in the presence of equal concentration of cAMP.
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In Vivo——
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Synonyms——
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PathwayOthers
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TargetOther Targets
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RecptorEpac1|Epac2
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Research Area——
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Indication——
Chemical Information
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CAS Number1383539-73-8
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Formula Weight339.45
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Molecular FormulaC19H21N3OS
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Purity>98% (HPLC)
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SolubilityIn Vitro:?DMSO : 50 mg/mL (147.30 mM)
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SMILESCc1ccc(C)c(CSc2nc(C3CCCC3)c(C#N)c(=O)[nH]2)c1
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Chemical Name——
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
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2,5,6,7-Tetrahydroxy...
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MS177
MS177 is an effective and fast-acting EZH2 degrader. MS177 is a PROTAC that consists of a CRBN ligand, linker, and a potent enzymatic EZH2 inhibitor C24 (C24 IC50): 12?nM). MS177 effectively depletes both canonical EZH2–PRC2 and noncanonical EZH2–cMyc complexes. MS177 induces leukaemia cell growth inhibition, apoptosis and cell cycle progression arrest.
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Ponceau S
Ponceau S (Acid Red 112) is the most commonly used stain for Western blotting binding with antibody-antigen, and stains the proteins on the membrane red.
