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BAY524
CAS No. 1445830-39-6
BAY524( —— )
Catalog No. M22177 CAS No. 1445830-39-6
BAY-524 is an inhibitor of Bub1(IC50 = 450 nM.human Bub1 in the presence of 2 mM ATP).
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 1 mL x 10 mM in DMSO | 188 | In Stock |
|
| 5MG | 186 | In Stock |
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| 10MG | 314 | In Stock |
|
| 25MG | 508 | In Stock |
|
| 50MG | 681 | In Stock |
|
| 100MG | 921 | In Stock |
|
| 200MG | Get Quote | In Stock |
|
| 500MG | Get Quote | In Stock |
|
| 1G | Get Quote | In Stock |
|
Biological Information
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Product NameBAY524
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NoteResearch use only, not for human use.
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Brief DescriptionBAY-524 is an inhibitor of Bub1(IC50 = 450 nM.human Bub1 in the presence of 2 mM ATP).
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DescriptionBAY-524 is an inhibitor of Bub1(IC50 = 450 nM.human Bub1 in the presence of 2 mM ATP).
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In VitroBAY-524 inhibits the recombinant catalytic domain of human Bub1 with an IC50 of 450 nM.BAY-524 (7-10 μM or 0-30 μM; 14 h or 1 h) specifically inhibit Bub1 kinase.BAY-524 (7 μM , 12 h or 7 μM, 12 μM, 3 h) affects Sgo1 and Sgo2 localization and chromatid cohesion in cells.BAY-524 (7 μM, 10 μM) affects localization and activity of the CPC.BAY-524 (7 μM, 2 h) exerts additive effect on centromere association of CPC.BAY-524 (7 μM, 48 h) marginally affects SAC signaling.BAY-524 (7 μM, 10 μM) sensitizes cells to low doses of paclitaxel. Western Blot Analysis Cell Line:hTERT-RPE1 (RPE1) and HeLa cells Concentration:7-10 μM Incubation Time:14 hResult:Drastically reduced T120 phosphorylation.Immunofluorescence Cell Line:RPE1 and HeLa cells Concentration:0-30 μM Incubation Time:1 hResult:Reduced histone H2A-T120 phosphorylation.
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In Vivo——
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Synonyms——
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PathwayOthers
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TargetOther Targets
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RecptorBub1
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Research Area——
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Indication——
Chemical Information
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CAS Number1445830-39-6
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Formula Weight482.48
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Molecular FormulaC24H24F2N6O3
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Purity>98% (HPLC)
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SolubilityDMSO:150 mg/mL?(310.89 mM;?Need ultrasonic)
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SMILESCCOc1cc(F)c(Cn2nc(c(C)c2OC)-c2ncc(OC)c(Nc3ccncc3)n2)c(F)c1
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Chemical Name——
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1.Baron AP, et al. Probing the catalytic functions of Bub1 kinase using the small molecule inhibitors BAY-320 and BAY-524. Elife. 2016 Feb 17;5. pii: e12187.
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