Okanin

Research use only, not for human use.

Okanin shows significant activities on both linoleic acid peroxidation inhibition and DPPH radical scavenging effect.

Okanin shows significant activities on both linoleic acid peroxidation inhibition and DPPH radical scavenging effect.Activity-guided fractionation of the EtOH extract of flowers of Bidens bipinnata L. have been furnished five flavonoids, sulfuretin(1), butein(2), 7,8,3 2,4 2-tetrahydroxyflavanone(3), maritimetin(4) and Okanin(5). All of the compounds showed significant activities on both linoleic acid peroxidation inhibition and DPPH radical scavenging effect. The evaluation for protective effect of isolated compounds against tacrine-induced cytotoxicity in human liver-derived Hep G2 cells was conducted. Compounds 1, 3, 4 and 5 showed significant protective effects with the EC50 values of 36.1±0.9, 23.3±0.7, 41.0±1.0 and 29.8±1.1 μM, respectively.

Okanin significantly inhibits LPS-induced TLR4 expression in BV-2 cells. Okanin inhibits the translocation of the NF-κB p65 subunit from the cytosol to the nucleus. Okanin significantly suppresses LPS-induced iNOS expression and also inhibites IL-6 and TNF-α production and mRNA expression in LPS-stimulated BV-2 cells.

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Immunology/Inflammation

TLR

TLR4|NF-κB

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484-76-4

288.3

C15H12O6

>98% (HPLC)

In Vitro:?DMSO : 16.67 mg/mL (57.83 mM)

C1=CC(=C(C=C1C=CC(=O)C2=C(C(=C(C=C2)O)O)O)O)O

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(-20℃)

With Ice Pack

≥ 2 years