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IQ3
CAS No. 312538-03-7
IQ3( —— )
Catalog No. M22014 CAS No. 312538-03-7
IQ3 is a selective inhibitor of JNK3(JNK3, JNK1 and JNK2 with Kd of 66 nM, 240 nM and 290 nM, respectively).
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 1 mL x 10 mM in DMSO | 84 | In Stock |
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| 5MG | 73 | In Stock |
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| 10MG | 111 | In Stock |
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| 25MG | 219 | In Stock |
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| 50MG | 343 | In Stock |
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| 100MG | 511 | In Stock |
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| 200MG | Get Quote | In Stock |
|
| 500MG | Get Quote | In Stock |
|
| 1G | Get Quote | In Stock |
|
Biological Information
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Product NameIQ3
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NoteResearch use only, not for human use.
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Brief DescriptionIQ3 is a selective inhibitor of JNK3(JNK3, JNK1 and JNK2 with Kd of 66 nM, 240 nM and 290 nM, respectively).
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DescriptionIQ3 is a selective inhibitor of JNK3(JNK3, JNK1 and JNK2 with Kd of 66 nM, 240 nM and 290 nM, respectively). IQ 3 inhibits NF-κB/AP1 transcriptional activity in THP1-Blue cells with IC50 of 1.4 μM, also inhibits TNF-α and IL-6 production in vitro.
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In VitroIQ-3 exhibits IC50 of 2.2 μM (TNF-α in human monoMac-6 cells), 1.5 μM (IL-6 in human monoMac-6 cells), 4.7 μM (TNF-α in human PBMCs), 9.1 μM (IL-6 in human PBMCs) and 6.1 μM (NO in murine J774.A1), respectively.IQ-3 exhibits an IC50 of 1.4 μM for inhibiting LPS-induced NF-κB/AP-1 transcriptional activity in human THP-1 Blue monocytic cells.IQ-3 is indeed a competitive inhibitor for the ATP binding site of JNK3. Cell Viability Assay Cell Line:PBMCs.Concentration:0-80 μM (200 ng/mL LPS).Incubation Time:30 min.Result:Downregulated TNF-α concentration (IC50 = 4.7 μM).
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In Vivo——
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Synonyms——
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PathwayMAPK/ERK Signaling
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TargetJNK
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RecptorJNK3|JNK1|JNK2
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Research Area——
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Indication——
Chemical Information
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CAS Number312538-03-7
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Formula Weight341.32
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Molecular FormulaC20H11N3O3
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Purity>98% (HPLC)
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SolubilityIn Vitro:?DMSO : 25 mg/mL (73.25 mM)
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SMILESO=C(ON=C1C2=CC=CC=C2C2=NC3=CC=CC=C3N=C12)C1=CC=CO1
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Chemical Name——
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
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D-JNKI-1
A cell-permeable peptide inhibitor of JNK kinase.
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Tanzisertib
Tanzisertib (CC-930) is a potent inhibitor of JNK1/2/3 with IC50s of 61/7/6 nM, respectively, with potential antifibrotic activity.Tanzisertib (CC-930) inhibits the formation of phospho-cJun in human PBMC stimulated by phorbol-12-myristate-13-acetate and phytohemeagglutinin (IC50=1 μM)[1] and it blocks the JNK pathway that is activated by pro-fibrotic cytokines in systemic sclerosis.
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c-JUN peptide
Peptide comprising residues 33 - 57 of the JNK binding (δ) domain of human c-Jun. Disrupts JNK/c-Jun interaction leading to inhibition of serum-induced c-Jun phosphorylation, up-regulation of p21cip/waf and modulation of inflammatory gene expression. Specifically induces apoptosis in HeLa tumor cells.
