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LQZ-7I
CAS No. 195822-23-2
LQZ-7I( —— )
Catalog No. M22010 CAS No. 195822-23-2
LQZ-7I is an inhibitor of surviving-targeting. It orally effectively inhibits xenograft tumor growth and induces survivin loss in tumors.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 1 mL x 10 mM in DMSO | 49 | In Stock |
|
| 5MG | 45 | In Stock |
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| 10MG | 76 | In Stock |
|
| 25MG | 155 | In Stock |
|
| 50MG | 245 | In Stock |
|
| 100MG | 384 | In Stock |
|
| 200MG | Get Quote | In Stock |
|
| 500MG | 877 | In Stock |
|
| 1G | Get Quote | In Stock |
|
Biological Information
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Product NameLQZ-7I
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NoteResearch use only, not for human use.
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Brief DescriptionLQZ-7I is an inhibitor of surviving-targeting. It orally effectively inhibits xenograft tumor growth and induces survivin loss in tumors.
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DescriptionLQZ-7I is an inhibitor of surviving-targeting. It orally effectively inhibits xenograft tumor growth and induces survivin loss in tumors.
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In VitroWestern Blot Analysis Cell Line:PC-3 or C4-2 cells Concentration:10 μM Incubation Time:0-6 hours Result:Reduced the expression of survivin.
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In VivoAnimal Model:6-week old male NSG mice Dosage:100 mg/kg; 200 μL vehicle (90% corn oil/10% DMSO) Administration:Oral gavage every other day for a total of ten treatments Result:Significantly suppressed tumor growth without any notable adverse effect on the mice as indicated by lacking changes in body weight and in wet weight of major organs at the end of the study.
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Synonyms——
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PathwayOthers
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TargetOther Targets
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RecptorSurvivin
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Research Area——
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Indication——
Chemical Information
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CAS Number195822-23-2
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Formula Weight348.35
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Molecular FormulaC20H14F2N4
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Purity>98% (HPLC)
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SolubilityDMSO:120mg/ml (344.48 Mm; Need ultrasonic)
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SMILESFC1=CC=C(NC2=NC3=CC=CC=C3N=C2NC2=CC=C(F)C=C2)C=C1
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Chemical Name——
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1.Robert Peery,et al. Synthesis and Identification of a Novel Lead Targeting Survivin Dimerization for Proteasome-Dependent Degradation. J Med Chem. 2020 Jun 9.
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