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TC-I2000

CAS No. 1159996-20-9

TC-I2000( —— )

Catalog No. M21933 CAS No. 1159996-20-9

TC-I2000 is an TRPM8 channel blocker. Inhibits icilin-induced TRPM8 channel activation in rTRPM8-expressing CHO cells with IC50 of 53 nM.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
Size Price / USD Stock Quantity
1 mL x 10 mM in DMSO 42 In Stock
5MG 29 In Stock
10MG 44 In Stock
25MG 77 In Stock
50MG 113 In Stock
100MG 170 In Stock
200MG 253 In Stock
500MG Get Quote In Stock
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Biological Information

  • Product Name
    TC-I2000
  • Note
    Research use only, not for human use.
  • Brief Description
    TC-I2000 is an TRPM8 channel blocker. Inhibits icilin-induced TRPM8 channel activation in rTRPM8-expressing CHO cells with IC50 of 53 nM.
  • Description
    TC-I2000 is an TRPM8 channel blocker. Inhibits icilin-induced TRPM8 channel activation in rTRPM8-expressing CHO cells with IC50 of 53 nM.
  • In Vitro
    ——
  • In Vivo
    ——
  • Synonyms
    ——
  • Pathway
    Membrane Transporter/Ion Channel
  • Target
    TRP/TRPV Channel
  • Recptor
    TRPM8
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    1159996-20-9
  • Formula Weight
    414.4
  • Molecular Formula
    C23H18F4N2O?
  • Purity
    >98% (HPLC)
  • Solubility
    ——
  • SMILES
    Fc1ccc(NC(=O)N2CCc3ccccc3C2c2ccc(cc2)C(F)(F)F)cc1
  • Chemical Name
    ——

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1.Tamayo N A , Bo Y , Gore V , et al. Fused Piperidines as a Novel Class of Potent and Orally Available Transient Receptor Potential Melastatin Type 8 (TRPM8) Antagonists[J]. Journal of Medicinal Chemistry, 2012, 55(4):1593-1611.
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