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Pep 2-8

CAS No. 1541011-97-5

Pep 2-8( —— )

Catalog No. M21916 CAS No. 1541011-97-5

Proprotein convertase subtilisin/kexin type 9 (PCSK9) inhibitor. Potent inhibitor of PCSK9 binding to LDL receptor (IC50 = 0.8 μM). Restores LDL uptake in HepG2 cells treated with PCSK9.

Purity : >98% (HPLC)

COA

Datasheet

HNMR

HPLC

MSDS

Handing Instructions

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Biological Information

Product Name

Pep 2-8
Note

Research use only, not for human use.
Brief Description

Proprotein convertase subtilisin/kexin type 9 (PCSK9) inhibitor. Potent inhibitor of PCSK9 binding to LDL receptor (IC50 = 0.8 μM). Restores LDL uptake in HepG2 cells treated with PCSK9.
Description

Proprotein convertase subtilisin/kexin type 9 (PCSK9) inhibitor. Potent inhibitor of PCSK9 binding to LDL receptor (IC50 = 0.8 μM). Restores LDL uptake in HepG2 cells treated with PCSK9.
In Vitro

Cell Viability Assay Cell Line:HepG2 cell.Concentration:15 μg/mL.Incubation Time:4 h.Result:Inhibited PCSK9 activity.
In Vivo

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Synonyms

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Pathway

Others
Target

Other Targets
Recptor

Other Targets
Research Area

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Indication

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Chemical Information

CAS Number

1541011-97-5
Formula Weight

1715.88
Molecular Formula

C83H110N16O24
Purity

>98% (HPLC)
Solubility

In Vitro:?DMSO : 100 mg/mL (58.28 mM)
SMILES

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Chemical Name

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Shipping & Storage Information

Storage

(-20℃)
Shipping

With Ice Pack
Stability

≥ 2 years

Reference

1. Zhang et al (2014) Identification of a small peptide that inhibits PCSK9 protein binding to the low density lipoprotein receptor. J.Biol.Chem.

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