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Home - Products - Cell Cycle/DNA Damage - ROCK - Cucurbitacin A

Cucurbitacin A

CAS No. 6040-19-3

Cucurbitacin A( —— )

Catalog No. M21905 CAS No. 6040-19-3

Cucurbitacin I, cytotoxic triterpenoid sterols isolated from plants, elicits the formation of actin/phospho-myosin II co-aggregates by stimulation of the RhoA/ROCK pathway and inhibition of LIM-Kinase.

Purity : >98% (HPLC)

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Biological Information

  • Product Name
    Cucurbitacin A
  • Note
    Research use only, not for human use.
  • Brief Description
    Cucurbitacin I, cytotoxic triterpenoid sterols isolated from plants, elicits the formation of actin/phospho-myosin II co-aggregates by stimulation of the RhoA/ROCK pathway and inhibition of LIM-Kinase.
  • Description
    Cucurbitacin I, cytotoxic triterpenoid sterols isolated from plants, elicits the formation of actin/phospho-myosin II co-aggregates by stimulation of the RhoA/ROCK pathway and inhibition of LIM-Kinase.
  • In Vitro
    Cucurbitacin A inhibits the proliferation of A549 and BEL-7402 cells with IC50 values of 0.4 and 0.3 μM, respectively.
  • In Vivo
    ——
  • Synonyms
    ——
  • Pathway
    Cell Cycle/DNA Damage
  • Target
    ROCK
  • Recptor
    ROCK
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    6040-19-3
  • Formula Weight
    574.7
  • Molecular Formula
    C32H46O9
  • Purity
    >98% (HPLC)
  • Solubility
    Soluble in Chloroform,Dichloromethane,Ethyl Acetate,DMSO,Acetone,etc.
  • SMILES
    CC(=O)OC(C)(C)C=CC(=O)C(C)(C1C(CC2(C1(CC(=O)C3(C2CC=C4C3CC(C(=O)C4(C)C)O)CO)C)C)O)O
  • Chemical Name
    ——

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Cucurbitacin I elicits the formation of actin/phospho-myosin II co-aggregates by stimulation of the RhoA/ROCK pathway and inhibition of LIM-kinase.Biochem. Pharmacol., 2015, 102:45-63.
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