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McN3716
CAS No. 69207-52-9
McN3716( Methyl palmoxirate | NSC359682 )
Catalog No. M21897 CAS No. 69207-52-9
Inhibition of brain mitochondrial β-oxidation by McN3716 (Methyl palmoxirate, MEP) significantly reduces the levels of all measured HETE and epoxytrienoic acids (EET), nonenzymatic auto-oxidative metabolites of ARA.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
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| Size | Price / USD | Stock | Quantity |
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| 10MG | 1140 | In Stock |
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| 25MG | 1511 | In Stock |
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| 50MG | 1841 | In Stock |
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| 100MG | 2325 | In Stock |
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| 200MG | Get Quote | In Stock |
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| 500MG | 4650 | In Stock |
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Biological Information
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Product NameMcN3716
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NoteResearch use only, not for human use.
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Brief DescriptionInhibition of brain mitochondrial β-oxidation by McN3716 (Methyl palmoxirate, MEP) significantly reduces the levels of all measured HETE and epoxytrienoic acids (EET), nonenzymatic auto-oxidative metabolites of ARA.
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DescriptionInhibition of brain mitochondrial β-oxidation by McN3716 (Methyl palmoxirate, MEP) significantly reduces the levels of all measured HETE and epoxytrienoic acids (EET), nonenzymatic auto-oxidative metabolites of ARA, by 23% to 44% and 32% to 50% compared with vehicle-injected rats, respectively, except for 15-HETE which was unaffected. There is a significant 34% reduction in the level of 6-keto-PGF1α, a byproduct of PGI2 (prostacyclin) in McN3716-treated rats. Similarly, the brain level of hydroxyeicosapentaenoic acids, nonenzymatic auto-oxidative metabolites of EPA, is reduced by 35% to 76% upon McN3716 treatment relative to vehicle.
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In Vitro——
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In VivoInhibition of brain mitochondrial β-oxidation by McN3716 (Methyl palmoxirate, MEP) significantly reduces the levels of all measured HETE and epoxytrienoic acids (EET), nonenzymatic auto-oxidative metabolites of ARA, by 23% to 44% and 32% to 50% compared with vehicle-injected rats, respectively, except for 15-HETE which was unaffected. There is a significant 34% reduction in the level of 6-keto-PGF1α, a byproduct of PGI2 (prostacyclin) in McN3716-treated rats. Similarly, the brain level of hydroxyeicosapentaenoic acids, nonenzymatic auto-oxidative metabolites of EPA, is reduced by 35% to 76% upon McN3716 treatment relative to vehicle.
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SynonymsMethyl palmoxirate | NSC359682
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PathwayOthers
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TargetOther Targets
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RecptorCarnitine palmitoyltransferase I (CPT-1)
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Research Area——
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Indication——
Chemical Information
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CAS Number69207-52-9
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Formula Weight298.46
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Molecular FormulaC??H??O?
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Purity>98% (HPLC)
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Solubility——
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SMILESO=C(C1(CCCCCCCCCCCCCC)OC1)OC
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Chemical Name——
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Chen CT, et al. Inhibiting mitochondrial β-oxidation selectively reduces levels of nonenzymatic oxidative polyunsaturated fatty acid metabolites in the brain. J Cereb Blood Flow Metab. 2014 Mar;34(3):376-9.
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