Homo-PROTAC cereblon degrader 1( —— )

Catalog No. M21750 CAS No. 2244520-98-5

COA

Datasheet

HNMR

HPLC

MSDS

Handing Instructions

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Product Name

Homo-PROTAC cereblon degrader 1
Note

Research use only, not for human use.
Brief Description

Homo-PROTAC cereblon degrader 1 (compound 15a) is a highly potent and efficient cereblon (CRBN) degrader with only minimal effects on IKZF1 and IKZF3.
Description

Homo-PROTAC cereblon degrader 1 (compound 15a) is a highly potent and efficient cereblon (CRBN) degrader with only minimal effects on IKZF1 and IKZF3.
In Vitro

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In Vivo

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Synonyms

——
Pathway

PROTACs
Target

PROTAC
Recptor

——
Research Area

——
Indication

——

CAS Number

2244520-98-5
Formula Weight

660.63
Molecular Formula

C??H??N?O??
Purity

>98% (HPLC)
Solubility

DMSO : 200 mg/mL (302.74 mM; Need ultrasonic)
SMILES

O=C(N1C2CCC(NC2=O)=O)C3=CC=CC(NCCOCCOCCNC4=C5C(C(N(C6CCC(NC6=O)=O)C5=O)=O)=CC=C4)=C3C1=O
Chemical Name

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1. Steinebach C, et al. Homo-PROTACs for the Chemical Knockdown of Cereblon. ACS Chem Biol. 2018 Sep 21;13(9):2771-2782.

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