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Savolitinib
CAS No. 1313725-88-0
Savolitinib( —— )
Catalog No. M21727 CAS No. 1313725-88-0
Savolitinib (AZD-6094) is a potent, highly selective, and orally bioavailable c-Met inhibitor with IC50s of 5 nM and 3 nM for c-Met and p-Met.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 1 mL x 10 mM in DMSO | 93 | In Stock |
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| 2MG | 55 | In Stock |
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| 5MG | 88 | In Stock |
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| 10MG | 126 | In Stock |
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| 25MG | 211 | In Stock |
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| 50MG | 365 | In Stock |
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| 100MG | 555 | In Stock |
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| 200MG | Get Quote | In Stock |
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| 500MG | Get Quote | In Stock |
|
| 1G | Get Quote | In Stock |
|
Biological Information
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Product NameSavolitinib
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NoteResearch use only, not for human use.
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Brief DescriptionSavolitinib (AZD-6094) is a potent, highly selective, and orally bioavailable c-Met inhibitor with IC50s of 5 nM and 3 nM for c-Met and p-Met.
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DescriptionSavolitinib (AZD-6094) is a potent, highly selective, and orally bioavailable c-Met inhibitor with IC50s of 5 nM and 3 nM for c-Met and p-Met, respectively. Savolitinib (AZD-6094) selectively binds to and inhibits the activation of c-Met in an ATP-competitive manner, and disrupts c-Met signal transduction pathways. Antineoplastic activity.
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In Vitro——
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In VivoAnimal Model:U87MG xenograft model in athymic nude mice Dosage:1 mg/kg, 2.5 mg/kg and 10.0 mg/kg Administration:Oral administration; daily; for 21 days Result:Demonstrated dose-dependent tumor growth inhibition in a U87MG subcutaneous xenograft model.
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Synonyms——
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PathwayAngiogenesis
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Targetc-Met/HGFR
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Recptor——
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Research Area——
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Indication——
Chemical Information
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CAS Number1313725-88-0
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Formula Weight345.36
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Molecular FormulaC??H??N?
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Purity>98% (HPLC)
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SolubilityDMSO : 25 mg/mL (72.39 mM; Need ultrasonic);H2O : < 0.1 mg/mL (insoluble)
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SMILESCN1N=CC(C2=CN=C3C(N([C@H](C4=CN5C(C=C4)=NC=C5)C)N=N3)=N2)=C1
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Chemical Name——
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Jia H, et al. J Med Chem. 2014 Sep 25;57(18):7577-89.
2. Gavine PR, et al. Mol Oncol. 2015 Jan;9(1):323-33.
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