Savolitinib( —— )

Catalog No. M21727 CAS No. 1313725-88-0

COA

Datasheet

HNMR

HPLC

MSDS

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Product Name

Savolitinib
Note

Research use only, not for human use.
Brief Description

Savolitinib (AZD-6094) is a potent, highly selective, and orally bioavailable c-Met inhibitor with IC50s of 5 nM and 3 nM for c-Met and p-Met.
Description

Savolitinib (AZD-6094) is a potent, highly selective, and orally bioavailable c-Met inhibitor with IC50s of 5 nM and 3 nM for c-Met and p-Met, respectively. Savolitinib (AZD-6094) selectively binds to and inhibits the activation of c-Met in an ATP-competitive manner, and disrupts c-Met signal transduction pathways. Antineoplastic activity.
In Vitro

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In Vivo

Animal Model:U87MG xenograft model in athymic nude mice Dosage:1 mg/kg, 2.5 mg/kg and 10.0 mg/kg Administration:Oral administration; daily; for 21 days Result:Demonstrated dose-dependent tumor growth inhibition in a U87MG subcutaneous xenograft model.
Synonyms

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Pathway

Angiogenesis
Target

c-Met/HGFR
Recptor

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Research Area

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Indication

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CAS Number

1313725-88-0
Formula Weight

345.36
Molecular Formula

C??H??N?
Purity

>98% (HPLC)
Solubility

DMSO : 25 mg/mL (72.39 mM; Need ultrasonic);H2O : < 0.1 mg/mL (insoluble)
SMILES

CN1N=CC(C2=CN=C3C(N([C@H](C4=CN5C(C=C4)=NC=C5)C)N=N3)=N2)=C1
Chemical Name

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1. Jia H, et al. J Med Chem. 2014 Sep 25;57(18):7577-89. 2. Gavine PR, et al. Mol Oncol. 2015 Jan;9(1):323-33.

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