Cart
sales@molnova.com
Cyclo(RGDfK)
CAS No. 161552-3-0
Cyclo(RGDfK)( —— )
Catalog No. M21723 CAS No. 161552-3-0
Cyclo(RGDfK) is a synthetic lipopeptide inhibitor of αvβ3 integrin (IC50 = 1.33 nM).
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 5MG | 136 | In Stock |
|
| 10MG | 232 | In Stock |
|
| 25MG | 462 | In Stock |
|
| 100MG | Get Quote | In Stock |
|
| 200MG | Get Quote | In Stock |
|
| 500MG | Get Quote | In Stock |
|
| 1G | Get Quote | In Stock |
|
Biological Information
-
Product NameCyclo(RGDfK)
-
NoteResearch use only, not for human use.
-
Brief DescriptionCyclo(RGDfK) is a synthetic lipopeptide inhibitor of αvβ3 integrin (IC50 = 1.33 nM).
-
DescriptionCyclo(RGDfK) is a synthetic lipopeptide inhibitor of αvβ3 integrin (IC50 = 1.33 nM). Osteoblast cultures, which express αvβ5 and αvβ3 integrins, but not M21L cells that do not express these integrins, bind to cyclo(RGDfK)-coated surfaces. Cyclo(RGDfK) is taken up into tumors in vivo and in vitro and it has been polymerized or conjugated to various fluorophores, radiolabels, and peptide sequences for use in fluorescent and PET imaging to study tumor cell adhesion.
-
In Vitro——
-
In Vivo——
-
Synonyms——
-
PathwayCell Cycle/DNA Damage
-
TargetIntegrin
-
Recptorαvβ3 integrin
-
Research Area——
-
Indication——
Chemical Information
-
CAS Number161552-3-0
-
Formula Weight717.69
-
Molecular FormulaC29H42F3N9O9
-
Purity>98% (HPLC)
-
SolubilityWater,100 mg/mL (139.34 mM)
-
SMILESC1C(=O)NC(C(=O)NC(C(=O)NC(C(=O)NC(C(=O)N1)CCCN=C(N)N)CCCCN)CC2=CC=CC=C2)CC(=O)O.C(=O)(C(F)(F)F)O
-
Chemical Name——
Shipping & Storage Information
-
Storage(-20℃)
-
ShippingWith Ice Pack
-
Stability≥ 2 years
Reference
1. ?ime?ek, J., Notni, J., Kapp, T.G., et al. Benefits of NOPO as chelator in gallium-68 peptides, exemplified by preclinical characterization of 68Ga-NOPO-c(RGDfK). Mol. Pharm. 11(5), 1687-1695 (2014).
2. Dijkgraaf, I., Beer, A.J., and Wester, H.-J. Application of RGD-containing peptides as imaging probes for alphavbeta3 expression. Front. Biosci. (Landmark Ed.) 14, 887-899 (2009).
molnova catalog
related products
-
JK-273
A small molecule inhibitor of α4 integrin-dependent cell migration that functions by interacting with γ-parvin.
-
Echistatin, α1 isofo...
Potent irreversible αVβ3 integrin antagonist (Ki = 0.27 nM). Disrupts attachment of osteoclasts to bone and inhibits bone reabsorption (IC50 = 0.1 nM). Prevents ADP-induced platelet aggregation via inhibition of glycoprotein IIb/IIIa (GpIIb/IIIa, αIIbβ3) receptors (IC50 = 30 nM) in vitro.
-
Pyrintegrin
Pyrintegrin is an β1-integrin agonist that promotes embryonic stem cells' survival. Pyrintegrin can be used as a podocyte-protective agent.
