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OGG1-IN-O8

CAS No. 350997-39-6

OGG1-IN-O8( —— )

Catalog No. M21645 CAS No. 350997-39-6

OGG1-IN-O8 is an inhibitor of 8-oxoguanine DNA glycosylase 1 (OGG1;IC50 : 0.35 μM).

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
Size Price / USD Stock Quantity
1 mL x 10 mM in DMSO 52 In Stock
5MG 46 In Stock
10MG 81 In Stock
25MG 158 In Stock
50MG 230 In Stock
100MG 343 In Stock
200MG 514 In Stock
500MG Get Quote In Stock
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Biological Information

  • Product Name
    OGG1-IN-O8
  • Note
    Research use only, not for human use.
  • Brief Description
    OGG1-IN-O8 is an inhibitor of 8-oxoguanine DNA glycosylase 1 (OGG1;IC50 : 0.35 μM).
  • Description
    OGG1-IN-O8 is an inhibitor of 8-oxoguanine DNA glycosylase 1 (OGG1;IC50 : 0.35 μM).
  • In Vitro
    OGG1-IN-08 (50 μM) inhibits different DNA glycosylases activities, it inhibits?nei endonuclease VIII-like 1 DNA glycosylase (NEIL1)(84.56%), endonuclease III-like (NTH1)(63.09%), andFpg (91.74%), respectively.OGG1-IN-08 (10 μM) has a inhibitory OGG1 lyase activity on a substrate containing an AP site compared with the no inhibitor control.OGG1-IN-08 (10 μM) decreases the number of bases released into solution by OGG1 for both the 8-oxo-Gua and FapyGua compared with the no inhibitor.
  • In Vivo
    ——
  • Synonyms
    ——
  • Pathway
    Others
  • Target
    Other Targets
  • Recptor
    8-oxoguanine DNA glycosylase 1 (OGG1)
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    350997-39-6
  • Formula Weight
    261.12
  • Molecular Formula
    C9H6Cl2N2OS
  • Purity
    >98% (HPLC)
  • Solubility
    In Vitro:?DMSO : 25 mg/mL (95.74 mM)
  • SMILES
    NNC(=O)c1sc2cccc(Cl)c2c1Cl
  • Chemical Name
    34-Dichloro-benzo[b]thiophene-2-carboxylic acid hydrazide

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1.Lloyd R.S. Mccullough A.K. and Donley N.?Small molecule inhibitors of 8-oxoguanine DNA glycosylase-1 (OGG1).?(2016).
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