(R)-Serine

Research use only, not for human use.

(R)-Serine is an endogenous amino acidis a potent co-agonist at the NMDA glutamate receptor.

(R)-Serine is an endogenous amino acidis a potent co-agonist at the NMDA glutamate receptor.(In Vitro):(R)-Serine is synthesized from L-Ser by serine racemase (SR) and degraded by D-amino acid oxidase (DAAO) and SR. Distribution of D-Ser and NMDAR as determined by chemical measurement and immunohistochemistry supports D-Ser as an endogenous coagonist acting on the glycine modulatory site of the NR1 subunits of the NMDAR.(In Vivo):(R)-Serine (10 g/L; p.o.; throughout 8 weeks) regulates HFD induced weight gain.

(R)-Serine is synthesized from L-Ser by serine racemase (SR) and degraded by D-amino acid oxidase (DAAO) and SR. Distribution of D-Ser and NMDAR as determined by chemical measurement and immunohistochemistry supports D-Ser as an endogenous coagonist acting on the glycine modulatory site of the NR1 subunits of the NMDAR.

(R)-Serine (10 g/L; p.o.; throughout 8 weeks) regulates HFD induced weight gain. Animal Model:Four week old male C57Bl/6 miceDosage:10 g/LAdministration:Oral administration (drinking water supplemented with 10 g/l D-serine); throughout 8 weeksResult:Showed strongly reduced weight gain during the first week of supplementation with paralleled weight gain to HFD fed mice, but no catch up thereafter.

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Membrane Transporter/Ion Channel

NMDAR

NMDA receptor

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312-84-5

105.09

C3H7NO3

>98% (HPLC)

H2O:50 mg/mL (475.78 mM)

N[C@H](CO)C(O)=O

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(-20℃)

With Ice Pack

≥ 2 years