Gadobutrol( ZK 135079 )

Catalog No. M21600 CAS No. 770691-21-9

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Product Name

Gadobutrol
Note

Research use only, not for human use.
Brief Description

Gadobutrol is a nonionic paramagnetic contrast agent developed for tissue contrast enhancement in magnetic resonance imaging (MRI).
Description

Gadobutrol is a nonionic paramagnetic contrast agent developed for tissue contrast enhancement in magnetic resonance imaging (MRI).(In Vitro):Gadobutrol leads to a gradual decrease in cell density with increasing concentration under neutron irradiation.(In Vivo):Gadobutrol (intravenous injection, 200 mM, once, a week) can significantly enhance intracerebroventricular cell signaling in female C57BL/6 N mice.
In Vitro

Gadobutrol leads to a gradual decrease in cell density with increasing concentration under neutron irradiation. Cell Viability Assay Cell Line:Human melanoma cell line Sk-Mel-28 Concentration:0-30 mM Incubation Time:1 hour Result:Showed a decrease in cell density to 26% at 30 mM while to 80% with no gadobutrol under neutron irradiation.
In Vivo

Gadobutrol (intravenous injection, 200 mM, once, a week) can significantly enhance intracerebroventricular cell signaling in female C57BL/6 N mice. Animal Model:Female C57BL/6 N mice, 11-13 weeks, 21-23 g)Dosage:200 mM Administration:Intravenous injection; once; a week Result:Enhanced cells signal in the habenula, hippocampal formation, and locus coeruleus.
Synonyms

ZK 135079
Pathway

Others
Target

Other Targets
Recptor

Others
Research Area

Neurological Disease
Indication

Neoplastic CNS Lesions

CAS Number

770691-21-9
Formula Weight

604.71
Molecular Formula

C18H31GdN4O9
Purity

>98% (HPLC)
Solubility

H2O:20 mg/mL (33.07 mM; Need ultrasonic)
SMILES

OC[C@H](O)[C@@H]1CO[Gd]234567OC(=O)C[N]22CC[N]3(CC[N]14CC[N]5(CC2)CC(=O)O6)CC(=O)O7
Chemical Name

——

1.Cheng KT. Gadobutrol. Molecular Imaging and Contrast Agent Database (MICAD)

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