5'-Fluoroindirubinoxime( 5'-FIO )

Catalog No. M21594 CAS No. 861214-33-7

COA

Datasheet

HNMR

HPLC

MSDS

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Product Name

5'-Fluoroindirubinoxime
Note

Research use only, not for human use.
Brief Description

5'-Fluoroindirubinoxime is a potent FLT3 inhibitor( IC50 : 15 nM).
Description

5'-Fluoroindirubinoxime is a potent FLT3 inhibitor( IC50 : 15 nM).
In Vitro

5'-Fluoroindirubinoxime (5’-FIO, compound 13) exhibits IC50 values of 1.53 μM and 1.27 μM for VEGFR2 and Aurora A, respectively.5'-Fluoroindirubinoxime (5’-FIO) exhibits IC50 values of 12.2 μM, 2.1 μM, 3.4 μM and 5.1 μM in A549, SNU-638, HT-1080 and RK3E-ras cancer cells, respectively. 5'-Fluoroindirubinoxime (5’-FIO) induces the apoptosis in RK3E-ras cells.
In Vivo

5'-Fluoroindirubinoxime (5’-FIO, 10 μmol/L/100 μL (~2.95 mg/mL) every other day beginning on day 6, S.C..) exhibits significant anti-tumor activity in rats. Animal Model:Rat tumor model based RK3E-ras cells.Dosage:S.C..Administration:10 μmol/L/100 μL (~2.95 mg/mL) every other day beginning on day 6.Result:Effectively inhibited tumor growth.
Synonyms

5'-FIO
Pathway

Angiogenesis
Target

FLT
Recptor

FLT3
Research Area

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Indication

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1. Kim SA et al. Antitumor activity of novel indirubin derivatives in rat tumor model. Clin Cancer Res. 2007 Jan 1;13(1):253-9.

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