5'-Fluoroindirubinoxime

CAS No. 861214-33-7

5'-Fluoroindirubinoxime( 5'-FIO )

Catalog No. M21594 CAS No. 861214-33-7

5'-Fluoroindirubinoxime is a potent FLT3 inhibitor( IC50 : 15 nM).

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
Size Price / USD Stock Quantity
1 mL x 10 mM in DMSO 103 In Stock
5MG 93 In Stock
10MG 148 In Stock
25MG 275 In Stock
50MG 398 In Stock
100MG 579 In Stock
200MG Get Quote In Stock
500MG Get Quote In Stock
1G Get Quote In Stock

Biological Information

  • Product Name
    5'-Fluoroindirubinoxime
  • Note
    Research use only, not for human use.
  • Brief Description
    5'-Fluoroindirubinoxime is a potent FLT3 inhibitor( IC50 : 15 nM).
  • Description
    5'-Fluoroindirubinoxime is a potent FLT3 inhibitor( IC50 : 15 nM).
  • In Vitro
    5'-Fluoroindirubinoxime (5’-FIO, compound 13) exhibits IC50 values of 1.53 μM and 1.27 μM for VEGFR2 and Aurora A, respectively.5'-Fluoroindirubinoxime (5’-FIO) exhibits IC50 values of 12.2 μM, 2.1 μM, 3.4 μM and 5.1 μM in A549, SNU-638, HT-1080 and RK3E-ras cancer cells, respectively. 5'-Fluoroindirubinoxime (5’-FIO) induces the apoptosis in RK3E-ras cells.
  • In Vivo
    5'-Fluoroindirubinoxime (5’-FIO, 10 μmol/L/100 μL (~2.95 mg/mL) every other day beginning on day 6, S.C..) exhibits significant anti-tumor activity in rats. Animal Model:Rat tumor model based RK3E-ras cells.Dosage:S.C..Administration:10 μmol/L/100 μL (~2.95 mg/mL) every other day beginning on day 6.Result:Effectively inhibited tumor growth.
  • Synonyms
    5'-FIO
  • Pathway
    Angiogenesis
  • Target
    FLT
  • Recptor
    FLT3
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    861214-33-7
  • Formula Weight
    295.27
  • Molecular Formula
    C16H10FN3O2
  • Purity
    >98% (HPLC)
  • Solubility
    DMSO:83.33 mg/mL (282.22 mM; Need ultrasonic)
  • SMILES
    Oc1[nH]c2ccc(F)cc2c1-c1[nH]c2ccccc2c1N=O
  • Chemical Name
    ——

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Kim SA et al. Antitumor activity of novel indirubin derivatives in rat tumor model. Clin Cancer Res. 2007 Jan 1;13(1):253-9.
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